GO Annotations Graph

• Symbol: Htt
• Name: huntingtin
• ID: MGI:96067

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:164563
Molecular Function	GO:0050809	diazepam binding	IMP	J:53700
Molecular Function	GO:0034452	dynactin binding	ISO	J:164563
Molecular Function	GO:0045505	dynein intermediate chain binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005522	profilin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:145963
Molecular Function	GO:0005515	protein binding	IPI	J:245269
Molecular Function	GO:0005515	protein binding	IPI	J:162096
Molecular Function	GO:0005515	protein binding	IPI	J:277863
Molecular Function	GO:0005515	protein binding	IPI	J:200423
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:220288
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:91294
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:91294
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:81675
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:47245
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	IPI	J:138707
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0005776	autophagosome	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:77468
Cellular Component	GO:0030424	axon	IDA	J:34936
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0005814	centriole	IDA	J:178446
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:220288
Cellular Component	GO:0005737	cytoplasm	IDA	J:34936
Cellular Component	GO:0005737	cytoplasm	IDA	J:29604
Cellular Component	GO:0005737	cytoplasm	IDA	J:24940
Cellular Component	GO:0005737	cytoplasm	IDA	J:60937
Cellular Component	GO:0005737	cytoplasm	IDA	J:106763
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:91294
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:220707
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:165147
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:165147
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:165147
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:165147
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:165147
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:165147
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:165147
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	IDA	J:94966
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0071598	neuronal ribonucleoprotein granule	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9023599
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:220707
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0099523	presynaptic cytosol	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Biological Process	GO:0009653	anatomical structure morphogenesis	IMP	J:103454
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:103454
Biological Process	GO:0008306	associative learning	IMP	J:118627
Biological Process	GO:0008088	axo-dendritic transport	IMP	J:92971
Biological Process	GO:0007420	brain development	IMP	J:114544
Biological Process	GO:0090398	cellular senescence	IMP	J:106763
Biological Process	GO:0007417	central nervous system development	IMP	J:44391
Biological Process	GO:0000052	citrulline metabolic process	IMP	J:121854
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:67074
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:65520
Biological Process	GO:0007212	dopamine receptor signaling pathway	IMP	J:123681
Biological Process	GO:0009790	embryo development	IMP	J:44391
Biological Process	GO:0009790	embryo development	IMP	J:114544
Biological Process	GO:0009790	embryo development	IMP	J:44391
Biological Process	GO:0007029	endoplasmic reticulum organization	IMP	J:102831
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	J:106641
Biological Process	GO:0016197	endosomal transport	IMP	J:106641
Biological Process	GO:0000132	establishment of mitotic spindle orientation	ISO	J:164563
Biological Process	GO:0007369	gastrulation	IMP	J:27183
Biological Process	GO:0007369	gastrulation	IMP	J:29267
Biological Process	GO:0007369	gastrulation	IMP	J:25941
Biological Process	GO:0007030	Golgi organization	ISO	J:164563
Biological Process	GO:0007625	grooming behavior	IMP	J:61490
Biological Process	GO:0042445	hormone metabolic process	IMP	J:61687
Biological Process	GO:0042445	hormone metabolic process	IMP	J:53776
Biological Process	GO:0030073	insulin secretion	IMP	J:53776
Biological Process	GO:0019244	lactate biosynthetic process from pyruvate	IMP	J:125228
Biological Process	GO:0007612	learning	IMP	J:112811
Biological Process	GO:0007611	learning or memory	IMP	J:106763
Biological Process	GO:0007626	locomotory behavior	IMP	J:71624
Biological Process	GO:0007626	locomotory behavior	IMP	J:67074
Biological Process	GO:0007626	locomotory behavior	IMP	J:79137
Biological Process	GO:0007626	locomotory behavior	IMP	J:85298
Biological Process	GO:0007626	locomotory behavior	IMP	J:61490
Biological Process	GO:0007626	locomotory behavior	IMP	J:106763
Biological Process	GO:0007626	locomotory behavior	IMP	J:65520
Biological Process	GO:0007626	locomotory behavior	IMP	J:25941
Biological Process	GO:0007626	locomotory behavior	IMP	J:123681
Biological Process	GO:0099111	microtubule-based transport	IBA	J:265628
Biological Process	GO:0006839	mitochondrial transport	IMP	J:92971
Biological Process	GO:0007005	mitochondrion organization	IMP	J:106641
Biological Process	GO:0051028	mRNA transport	ISO	J:155856
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:106641
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:29267
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:53700
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:91294
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0021990	neural plate formation	IMP	J:25941
Biological Process	GO:0022008	neurogenesis	IMP	J:65520
Biological Process	GO:0048666	neuron development	IMP	J:53700
Biological Process	GO:0048666	neuron development	IMP	J:25941
Biological Process	GO:0048666	neuron development	IMP	J:114544
Biological Process	GO:0021988	olfactory lobe development	IMP	J:85298
Biological Process	GO:0048341	paraxial mesoderm formation	IMP	J:103454
Biological Process	GO:0030072	peptide hormone secretion	IMP	J:79137
Biological Process	GO:0030072	peptide hormone secretion	IMP	J:53776
Biological Process	GO:1905337	positive regulation of aggrephagy	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1903599	positive regulation of autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0045724	positive regulation of cilium assembly	ISO	J:164563
Biological Process	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:1904504	positive regulation of lipophagy	ISO	J:164563
Biological Process	GO:1905505	positive regulation of motile cilium assembly	IMP	J:178446
Biological Process	GO:1902857	positive regulation of non-motile cilium assembly	IMP	J:178446
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IDA	J:165147
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IMP	J:165147
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IDA	J:165147
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IDA	J:165147
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IEP	J:165147
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IDA	J:165147
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IMP	J:165147
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0071539	protein localization to centrosome	IMP	J:178446
Biological Process	GO:0071539	protein localization to centrosome	IMP	J:178446
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:106641
Biological Process	GO:0019805	quinolinate biosynthetic process	IMP	J:111237
Biological Process	GO:0019805	quinolinate biosynthetic process	IMP	J:111237
Biological Process	GO:1905289	regulation of CAMKK-AMPK signaling cascade	ISO	J:164563
Biological Process	GO:2000479	regulation of cAMP-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:2000479	regulation of cAMP-dependent protein kinase activity	IMP	J:176978
Biological Process	GO:0010468	regulation of gene expression	IMP	J:176978
Biological Process	GO:1904580	regulation of intracellular mRNA localization	ISO	J:155856
Biological Process	GO:0043523	regulation of neuron apoptotic process	IMP	J:176978
Biological Process	GO:0043666	regulation of phosphoprotein phosphatase activity	ISO	J:164563
Biological Process	GO:1900180	regulation of protein localization to nucleus	IMP	J:176978
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:119836
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:119836
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:54551
Biological Process	GO:0051592	response to calcium ion	IMP	J:99425
Biological Process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0035176	social behavior	IMP	J:54906
Biological Process	GO:0007283	spermatogenesis	IMP	J:65520
Biological Process	GO:0021756	striatum development	IMP	J:65412
Biological Process	GO:0021756	striatum development	IMP	J:65412
Biological Process	GO:0021756	striatum development	IMP	J:123681
Biological Process	GO:0000050	urea cycle	IMP	J:121854
Biological Process	GO:0047496	vesicle transport along microtubule	ISO	J:164563
Biological Process	GO:0047496	vesicle transport along microtubule	IDA	J:91294
Biological Process	GO:0008542	visual learning	IMP	J:25941
Biological Process	GO:0042297	vocal learning	ISO	J:164563