GO Annotations Graph

• Symbol: Nrg1
• Name: neuregulin 1
• ID: MGI:96083

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0045499	chemorepellent activity	IDA	J:184363
Molecular Function	GO:0005176	ErbB-2 class receptor binding	IGI	J:42549
Molecular Function	GO:0005176	ErbB-2 class receptor binding	IDA	J:70080
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:164563
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:155532
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	IBA	J:265628
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:247763
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:34905
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:247763
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:106042
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:34905
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:157327
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:32778
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	ISO	J:91050
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:158973
Cellular Component	GO:0005737	cytoplasm	IDA	J:50592
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:34905
Cellular Component	GO:0005615	extracellular space	ISO	J:247763
Cellular Component	GO:0005615	extracellular space	ISO	J:247763
Cellular Component	GO:0005615	extracellular space	ISO	J:34905
Cellular Component	GO:0005615	extracellular space	ISO	J:157327
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263394
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263394
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263394
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	EXP	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IPI	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IMP	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0097471	mossy fiber rosette	IDA	J:326641
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:29667
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:50592
Cellular Component	GO:0005886	plasma membrane	IDA	J:70080
Cellular Component	GO:0098794	postsynapse	IDA	J:217137
Cellular Component	GO:0098794	postsynapse	IDA	J:217137
Cellular Component	GO:0098794	postsynapse	IDA	J:217137
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:326641
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:326641
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:326641
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:326641
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:22296
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Biological Process	GO:0048513	animal organ development	IBA	J:265628
Biological Process	GO:0003161	cardiac conduction system development	IDA	J:78367
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:119151
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	ISO	J:164563
Biological Process	GO:0048738	cardiac muscle tissue development	IDA	J:210551
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0000902	cell morphogenesis	IDA	J:42549
Biological Process	GO:0008283	cell population proliferation	ISO	J:164563
Biological Process	GO:0021842	chemorepulsion involved in interneuron migration from the subpallium to the cortex	IMP	J:184363
Biological Process	GO:0060956	endocardial cell differentiation	ISO	J:164563
Biological Process	GO:0038127	ERBB signaling pathway	ISO	J:164563
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	ISO	J:34905
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	ISO	J:157327
Biological Process	GO:0038129	ERBB3 signaling pathway	ISO	J:164563
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:164563
Biological Process	GO:0038130	ERBB4 signaling pathway	IDA	J:106042
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:247763
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:247763
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:34905
Biological Process	GO:0010001	glial cell differentiation	IMP	J:82745
Biological Process	GO:0021781	glial cell fate commitment	IDA	J:166449
Biological Process	GO:0007507	heart development	IMP	J:29971
Biological Process	GO:0007507	heart development	IMP	J:45302
Biological Process	GO:0007507	heart development	IMP	J:33038
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007626	locomotory behavior	IMP	J:62377
Biological Process	GO:0000165	MAPK cascade	IDA	J:34173
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0007517	muscle organ development	IMP	J:80793
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:217815
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:2000853	negative regulation of corticosterone secretion	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:91050
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:2001223	negative regulation of neuron migration	IDA	J:184363
Biological Process	GO:0042177	negative regulation of protein catabolic process	IDA	J:160700
Biological Process	GO:0051048	negative regulation of secretion	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IMP	J:33038
Biological Process	GO:0048663	neuron fate commitment	IMP	J:70080
Biological Process	GO:0001764	neuron migration	IGI	J:42549
Biological Process	GO:0045213	neurotransmitter receptor metabolic process	IMP	J:39800
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:116863
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:29971
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:45302
Biological Process	GO:0048680	positive regulation of axon regeneration	ISO	J:155856
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	IGI	J:144171
Biological Process	GO:2000727	positive regulation of cardiac muscle cell differentiation	IMP	J:119151
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:210551
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:34905
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:170361
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:170361
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:170361
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:22296
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:58616
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:160700
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	IDA	J:34173
Biological Process	GO:0010625	positive regulation of Schwann cell proliferation	ISO	J:155856
Biological Process	GO:0051155	positive regulation of striated muscle cell differentiation	IMP	J:119151
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IDA	J:263394
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IDA	J:263394
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	IMP	J:263394
Biological Process	GO:0030163	protein catabolic process	IDA	J:160700
Biological Process	GO:0043491	protein kinase B signaling	IDA	J:160700
Biological Process	GO:0032984	protein-containing complex disassembly	ISO	J:73065
Biological Process	GO:0045595	regulation of cell differentiation	IMP	J:52282
Biological Process	GO:0045595	regulation of cell differentiation	IMP	J:70080
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	ISO	J:164563
Biological Process	GO:1905606	regulation of presynapse assembly	IMP	J:159459
Biological Process	GO:1905606	regulation of presynapse assembly	IDA	J:159459
Biological Process	GO:1905606	regulation of presynapse assembly	IDA	J:159459
Biological Process	GO:1905606	regulation of presynapse assembly	IMP	J:159459
Biological Process	GO:1905606	regulation of presynapse assembly	IDA	J:159459
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:109028
Biological Process	GO:0051238	sequestering of metal ion	ISO	J:164563
Biological Process	GO:0007416	synapse assembly	IMP	J:60159
Biological Process	GO:0099560	synaptic membrane adhesion	IMP	J:326641
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:326641
Biological Process	GO:0099560	synaptic membrane adhesion	EXP	J:326641
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:326641
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:326641
Biological Process	GO:0099560	synaptic membrane adhesion	IPI	J:326641
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0055012	ventricular cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	ISO	J:164563
Biological Process	GO:0042060	wound healing	ISO	J:164563