Hmgb1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hmgb1
high mobility group box 1
MGI:96113

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008097	5S rRNA binding	ISO	J:155856
Molecular Function	GO:0003681	bent DNA binding	ISO	J:73065
Molecular Function	GO:0019958	C-X-C chemokine binding	ISO	J:164563
Molecular Function	GO:0010858	calcium-dependent protein kinase regulator activity	IDA	J:25262
Molecular Function	GO:0000402	crossed form four-way junction DNA binding	ISO	J:73065
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	IDA	J:28646
Molecular Function	GO:0005125	cytokine activity	ISO	J:73065
Molecular Function	GO:0005125	cytokine activity	IDA	J:25262
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0008301	DNA binding, bending	ISO	J:155856
Molecular Function	GO:0008301	DNA binding, bending	ISO	J:164563
Molecular Function	GO:0008301	DNA binding, bending	IBA	J:265628
Molecular Function	GO:0070182	DNA polymerase binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:154027
Molecular Function	GO:0003725	double-stranded RNA binding	IDA	J:154027
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:155856
Molecular Function	GO:0051861	glycolipid binding	ISO	J:155856
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0016829	lyase activity	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	EXP	J:326240
Molecular Function	GO:0000401	open form four-way junction DNA binding	ISO	J:73065
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0001786	phosphatidylserine binding	TAS	J:175331
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:244884
Molecular Function	GO:0005515	protein binding	IPI	J:233942
Molecular Function	GO:0005515	protein binding	IPI	J:187594
Molecular Function	GO:0005515	protein binding	IPI	J:220512
Molecular Function	GO:0030295	protein kinase activator activity	IDA	J:25262
Molecular Function	GO:0050786	RAGE receptor binding	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0003727	single-stranded RNA binding	IDA	J:154027
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Cellular Component	GO:0035868	alphav-beta3 integrin-HMGB1 complex	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000793	condensed chromosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:51416
Cellular Component	GO:0005737	cytoplasm	IDA	J:82501
Cellular Component	GO:0005737	cytoplasm	IDA	J:51416
Cellular Component	GO:0005737	cytoplasm	IDA	J:51416
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005769	early endosome	IDA	J:154027
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	J:175331
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:266466
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:82501
Cellular Component	GO:0005615	extracellular space	IDA	J:91269
Cellular Component	GO:0005615	extracellular space	IDA	J:28646
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IDA	J:82501
Cellular Component	GO:0005634	nucleus	IDA	J:266466
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:88808
Cellular Component	GO:0005634	nucleus	IDA	J:51416
Cellular Component	GO:0005634	nucleus	IDA	J:51416
Cellular Component	GO:0005634	nucleus	IDA	J:51416
Cellular Component	GO:0005634	nucleus	IDA	J:82501
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0043277	apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0006284	base-excision repair	IMP	J:124613
Biological Process	GO:0098761	cellular response to interleukin-7	IDA	J:260356
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:266466
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0006325	chromatin organization	IDA	J:139020
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0032392	DNA geometric change	ISO	J:73065
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0035767	endothelial cell chemotaxis	IDA	J:126243
Biological Process	GO:0001935	endothelial cell proliferation	IDA	J:126243
Biological Process	GO:0001654	eye development	IMP	J:55880
Biological Process	GO:0005980	glycogen catabolic process	IMP	J:55880
Biological Process	GO:0031507	heterochromatin formation	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0050930	induction of positive chemotaxis	ISO	J:73065
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	TAS	J:175331
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0030324	lung development	IMP	J:55880
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:154027
Biological Process	GO:0030099	myeloid cell differentiation	IDA	J:25262
Biological Process	GO:0030099	myeloid cell differentiation	IDA	J:28646
Biological Process	GO:0001773	myeloid dendritic cell activation	IMP	J:154027
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IDA	J:25262
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IDA	J:28646
Biological Process	GO:2000426	negative regulation of apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	ISO	J:164563
Biological Process	GO:0017055	negative regulation of RNA polymerase II transcription preinitiation complex assembly	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0097350	neutrophil clearance	ISO	J:164563
Biological Process	GO:0002270	plasmacytoid dendritic cell activation	IMP	J:154027
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:220512
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:73065
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:126243
Biological Process	GO:0045819	positive regulation of glycogen catabolic process	IMP	J:55880
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:154027
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:154027
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:154027
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:154027
Biological Process	GO:0032732	positive regulation of interleukin-1 production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:244884
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:154027
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	ISO	J:73065
Biological Process	GO:0032425	positive regulation of mismatch repair	ISO	J:164563
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:73065
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	IMP	J:244884
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	IDA	J:28646
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	IDA	J:25262
Biological Process	GO:1905455	positive regulation of myeloid progenitor cell differentiation	IDA	J:28646
Biological Process	GO:1905455	positive regulation of myeloid progenitor cell differentiation	IDA	J:25262
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	J:233938
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:25262
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	IDA	J:126243
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	IDA	J:233938
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	IDA	J:233938
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:55880
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:244884
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:154027
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0046598	positive regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0090303	positive regulation of wound healing	IDA	J:126243
Biological Process	GO:2000819	regulation of nucleotide-excision repair	IMP	J:139020
Biological Process	GO:0032072	regulation of restriction endodeoxyribonuclease activity	ISO	J:164563
Biological Process	GO:0002840	regulation of T cell mediated immune response to tumor cell	IDA	J:194127
Biological Process	GO:0002643	regulation of tolerance induction	IMP	J:137858
Biological Process	GO:0002643	regulation of tolerance induction	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0051384	response to glucocorticoid	IMP	J:55880
Biological Process	GO:0035711	T-helper 1 cell activation	ISO	J:164563
Biological Process	GO:0045063	T-helper 1 cell differentiation	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:55880
Biological Process	GO:0033151	V(D)J recombination	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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