GO Annotations Graph

• Symbol: Hmgb2
• Name: high mobility group box 2
• ID: MGI:96157

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:196872
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0008301	DNA binding, bending	ISO	J:164563
Molecular Function	GO:0008301	DNA binding, bending	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:305429
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:154027
Molecular Function	GO:0008289	lipid binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:153213
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:24361
Molecular Function	GO:0050786	RAGE receptor binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IDA	J:196872
Cellular Component	GO:0000785	chromatin	IDA	J:196872
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000793	condensed chromosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:221515
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:221515
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:221515
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IC	J:67968
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:144502
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IMP	J:221515
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0008584	male gonad development	IMP	J:67968
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:144502
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:196872
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:24361
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:196872
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:154027
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:154027
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	ISO	J:164563
Biological Process	GO:0032075	positive regulation of nuclease activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:67968
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:209829
Biological Process	GO:0072091	regulation of stem cell proliferation	IMP	J:209829
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:24361
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:221515
Biological Process	GO:0048545	response to steroid hormone	IMP	J:67968
Biological Process	GO:0007289	spermatid nucleus differentiation	IMP	J:119295
Biological Process	GO:0007283	spermatogenesis	IMP	J:67968