GO Annotations Graph

• Symbol: Hmgcr
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• ID: MGI:96159

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0120225	coenzyme A binding	ISO	J:164563
Molecular Function	GO:0030695	GTPase regulator activity	IGI	J:103691
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	ISO	J:164563
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA	J:265628
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:101230
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:1025
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:76988
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:40819
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:22362
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:78952
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:101203
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:86378
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	J:73910
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0050661	NADP binding	IEA	J:72247
Molecular Function	GO:0070402	NADPH binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	J:72247
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005778	peroxisomal membrane	ISO	J:164563
Cellular Component	GO:0005778	peroxisomal membrane	IBA	J:265628
Cellular Component	GO:0005777	peroxisome	IEA	J:60000
Biological Process	GO:0006695	cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0006695	cholesterol biosynthetic process	IDA	J:22362
Biological Process	GO:0006695	cholesterol biosynthetic process	IDA	J:101230
Biological Process	GO:0006695	cholesterol biosynthetic process	IDA	J:76988
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0015936	coenzyme A metabolic process	IEA	J:72247
Biological Process	GO:0009790	embryo development	IMP	J:86378
Biological Process	GO:0008299	isoprenoid biosynthetic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0060291	long-term synaptic potentiation	IGI	J:103691
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	IMP	J:268009
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IGI	J:103691
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IGI	J:103961
Biological Process	GO:0042177	negative regulation of protein catabolic process	IMP	J:268009
Biological Process	GO:0050709	negative regulation of protein secretion	IMP	J:268009
Biological Process	GO:0010664	negative regulation of striated muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0061045	negative regulation of wound healing	ISO	J:155856
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	IGI	J:103691
Biological Process	GO:0006694	steroid biosynthetic process	IEA	J:60000
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0016126	sterol biosynthetic process	IBA	J:265628
Biological Process	GO:0006743	ubiquinone metabolic process	ISO	J:155856
Biological Process	GO:0008542	visual learning	IGI	J:103691