GO Annotations Graph

• Symbol: Hmox1
• Name: heme oxygenase 1
• ID: MGI:96163

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0020037	heme binding	ISO	J:155856
Molecular Function	GO:0020037	heme binding	IBA	J:265628
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	ISO	J:155856
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	ISO	J:164563
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004630	phospholipase D activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005198	structural molecule activity	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:137484
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071243	cellular response to arsenic-containing substance	IDA	J:79339
Biological Process	GO:0071276	cellular response to cadmium ion	IDA	J:102659
Biological Process	GO:0072719	cellular response to cisplatin	IMP	J:185907
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:1904019	epithelial cell apoptotic process	IMP	J:185907
Biological Process	GO:0034101	erythrocyte homeostasis	ISO	J:164563
Biological Process	GO:0042167	heme catabolic process	ISO	J:155856
Biological Process	GO:0042167	heme catabolic process	ISO	J:164563
Biological Process	GO:0042167	heme catabolic process	IBA	J:265628
Biological Process	GO:0042168	heme metabolic process	IDA	J:102659
Biological Process	GO:0006788	heme oxidation	ISO	J:164563
Biological Process	GO:0006788	heme oxidation	IBA	J:265628
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:155856
Biological Process	GO:0097421	liver regeneration	ISO	J:155856
Biological Process	GO:0016236	macroautophagy	IMP	J:185907
Biological Process	GO:0016236	macroautophagy	IMP	J:185907
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0043392	negative regulation of DNA binding	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	ISO	J:155856
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0016242	negative regulation of macroautophagy	IMP	J:185907
Biological Process	GO:0032764	negative regulation of mast cell cytokine production	ISO	J:155856
Biological Process	GO:0043305	negative regulation of mast cell degranulation	ISO	J:155856
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	IMP	J:185907
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:185907
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	IDA	J:203507
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:155856
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0035094	response to nicotine	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	IBA	J:265628
Biological Process	GO:0007264	small GTPase mediated signal transduction	ISO	J:155856
Biological Process	GO:0002246	wound healing involved in inflammatory response	ISO	J:164563