GO Annotations Graph

• Symbol: Hr
• Name: lysine demethylase and nuclear receptor corepressor
• ID: MGI:96223

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031490	chromatin DNA binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0032454	histone H3K9 demethylase activity	IBA	J:265628
Molecular Function	GO:0140683	histone H3K9me/H3K9me2 demethylase activity	IEA	J:72245
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding	ISO	J:155856
Molecular Function	GO:0042809	nuclear vitamin D receptor binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0005515	protein binding	IPI	J:72326
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:155856
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:72326
Cellular Component	GO:0000785	chromatin	IBA	J:265628
Cellular Component	GO:0000118	histone deacetylase complex	ISO	J:155856
Cellular Component	GO:0000118	histone deacetylase complex	IBA	J:265628
Cellular Component	GO:0016604	nuclear body	IDA	J:72326
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0033169	histone H3-K9 demethylation	IBA	J:265628
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:72326
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628