GO Annotations Graph

• Symbol: Hrc
• Name: histidine rich calcium binding protein
• ID: MGI:96226

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:108863
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Biological Process	GO:0055074	calcium ion homeostasis	IDA	J:108863
Biological Process	GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0045823	positive regulation of heart contraction	ISO	J:164563
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:164563
Biological Process	GO:1901899	positive regulation of relaxation of cardiac muscle	ISO	J:164563
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	ISO	J:164563
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0008016	regulation of heart contraction	IDA	J:108863
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0033135	regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:164563
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:164563