GO Annotations Graph

• Symbol: Hspd1
• Name: heat shock protein 1 (chaperonin)
• ID: MGI:96242

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034186	apolipoprotein A-I binding	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone	IEA	J:72247
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0008035	high-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:120927
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0140030	modification-dependent protein binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0030135	coated vesicle	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:176455
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0031985	Golgi cisterna	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IDA	J:90654
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IDA	J:115064
Cellular Component	GO:0046696	lipopolysaccharide receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:156519
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0140494	migrasome	IDA	J:307067
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	IBA	J:265628
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:230728
Cellular Component	GO:0005739	mitochondrion	IDA	J:30898
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:307067
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	IDA	J:51799
Cellular Component	GO:0005739	mitochondrion	IDA	J:85083
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:233904
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:129427
Cellular Component	GO:0005739	mitochondrion	IDA	J:143
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:204433
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005782	peroxisomal matrix	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:30898
Cellular Component	GO:0030141	secretory granule	IDA	J:143
Cellular Component	GO:0097225	sperm midpiece	ISO	J:164563
Cellular Component	GO:0097524	sperm plasma membrane	IDA	J:91263
Cellular Component	GO:0042588	zymogen granule	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:155856
Biological Process	GO:0008637	apoptotic mitochondrial changes	IBA	J:265628
Biological Process	GO:0042113	B cell activation	ISO	J:164563
Biological Process	GO:0042100	B cell proliferation	ISO	J:164563
Biological Process	GO:0051702	biological process involved in interaction with symbiont	ISO	J:164563
Biological Process	GO:0098761	cellular response to interleukin-7	IDA	J:260356
Biological Process	GO:0032607	interferon-alpha production	IDA	J:120927
Biological Process	GO:0048291	isotype switching to IgG isotypes	ISO	J:164563
Biological Process	GO:0034514	mitochondrial unfolded protein response	IBA	J:265628
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0071866	negative regulation of apoptotic process in bone marrow cell	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IBA	J:265628
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IDA	J:120927
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IBA	J:265628
Biological Process	GO:0043032	positive regulation of macrophage activation	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	IDA	J:120927
Biological Process	GO:0050870	positive regulation of T cell activation	IBA	J:265628
Biological Process	GO:0002842	positive regulation of T cell mediated immune response to tumor cell	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0032729	positive regulation of type II interferon production	IBA	J:265628
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:94477
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:120927
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:73065
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:120927
Biological Process	GO:0006457	protein folding	IBA	J:265628
Biological Process	GO:0045041	protein import into mitochondrial intermembrane space	IBA	J:265628
Biological Process	GO:0042026	protein refolding	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	ISO	J:164563
Biological Process	GO:0042110	T cell activation	IBA	J:265628
Biological Process	GO:0042110	T cell activation	ISO	J:73065
Biological Process	GO:0042110	T cell activation	IGI	J:120927
Biological Process	GO:0042110	T cell activation	ISO	J:73065
Biological Process	GO:0042110	T cell activation	IDA	J:94477
Biological Process	GO:0042110	T cell activation	IDA	J:131964
Biological Process	GO:0042110	T cell activation	IDA	J:120927
Biological Process	GO:0032609	type II interferon production	IGI	J:120927
Biological Process	GO:0032609	type II interferon production	IDA	J:120927
Biological Process	GO:0032609	type II interferon production	IDA	J:94477