GO Annotations Graph

• Symbol: Hspa1a
• Name: heat shock protein 1A
• ID: MGI:96244

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	IBA	J:265628
Molecular Function	GO:0140545	ATP-dependent protein disaggregase activity	ISO	J:164563
Molecular Function	GO:0140545	ATP-dependent protein disaggregase activity	ISO	J:164563
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	ISO	J:164563
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	ISO	J:164563
Molecular Function	GO:0038177	death receptor agonist activity	ISO	J:164563
Molecular Function	GO:0031249	denatured protein binding	ISO	J:164563
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0051787	misfolded protein binding	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:142043
Molecular Function	GO:0005515	protein binding	IPI	J:269546
Molecular Function	GO:0044183	protein folding chaperone	ISO	J:164563
Molecular Function	GO:0044183	protein folding chaperone	ISO	J:164563
Molecular Function	GO:0044183	protein folding chaperone	IDA	J:276383
Molecular Function	GO:0044183	protein folding chaperone	IBA	J:265628
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:164563
Cellular Component	GO:0016235	aggresome	ISO	J:164563
Cellular Component	GO:0016235	aggresome	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0008180	COP9 signalosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:110647
Cellular Component	GO:0005737	cytoplasm	IDA	J:220288
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISS	J:137567
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	IBA	J:265628
Biological Process	GO:0006281	DNA repair	IMP	J:87581
Biological Process	GO:0007041	lysosomal transport	IMP	J:269546
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0006457	protein folding	IDA	J:276383
Biological Process	GO:0042026	protein refolding	IBA	J:265628
Biological Process	GO:1901673	regulation of mitotic spindle assembly	IBA	J:265628
Biological Process	GO:0009408	response to heat	IDA	J:142548
Biological Process	GO:0009408	response to heat	IMP	J:87581
Biological Process	GO:0000723	telomere maintenance	IMP	J:87581