GO Annotations Graph

• Symbol: Hsp90ab1
• Name: heat shock protein 90 alpha (cytosolic), class B member 1
• ID: MGI:96247

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IBA	J:265628
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0043008	ATP-dependent protein binding	ISO	J:164563
Molecular Function	GO:0002135	CTP binding	ISO	J:155856
Molecular Function	GO:0032564	dATP binding	ISO	J:155856
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0097718	disordered domain specific binding	IBA	J:265628
Molecular Function	GO:0070182	DNA polymerase binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:1990226	histone methyltransferase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	IPI	J:215871
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042277	peptide binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:247279
Molecular Function	GO:0005515	protein binding	IPI	J:74637
Molecular Function	GO:0005515	protein binding	IPI	J:259130
Molecular Function	GO:0005515	protein binding	IPI	J:203314
Molecular Function	GO:0005515	protein binding	IPI	J:187527
Molecular Function	GO:0005515	protein binding	IPI	J:146128
Molecular Function	GO:0005515	protein binding	IPI	J:75791
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:177748
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0044183	protein folding chaperone	IMP	J:276383
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IPI	J:259130
Molecular Function	GO:0019887	protein kinase regulator activity	IMP	J:215871
Molecular Function	GO:0017098	sulfonylurea receptor binding	ISO	J:155856
Molecular Function	GO:0048156	tau protein binding	IPI	J:259130
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	IBA	J:265628
Molecular Function	GO:0002134	UTP binding	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0034751	aryl hydrocarbon receptor complex	ISO	J:164563
Cellular Component	GO:0044295	axonal growth cone	IDA	J:259119
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0008180	COP9 signalosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:247279
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:276383
Cellular Component	GO:0005737	cytoplasm	IDA	J:125489
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0044294	dendritic growth cone	IDA	J:259119
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:1990565	HSP90-CDC37 chaperone complex	IDA	J:215871
Cellular Component	GO:1990565	HSP90-CDC37 chaperone complex	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:39331
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043025	neuronal cell body	IDA	J:259119
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:1990917	ooplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:259119
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:276383
Cellular Component	GO:0032991	protein-containing complex	IBA	J:265628
Cellular Component	GO:1990913	sperm head plasma membrane	ISO	J:155856
Biological Process	GO:0048675	axon extension	IMP	J:259119
Biological Process	GO:0034605	cellular response to heat	IMP	J:276383
Biological Process	GO:0034605	cellular response to heat	IBA	J:265628
Biological Process	GO:0071353	cellular response to interleukin-4	IDA	J:62630
Biological Process	GO:0021955	central nervous system neuron axonogenesis	IMP	J:259119
Biological Process	GO:0030010	establishment of cell polarity	IMP	J:259119
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:146128
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901799	negative regulation of proteasomal protein catabolic process	IMP	J:259130
Biological Process	GO:1901799	negative regulation of proteasomal protein catabolic process	ISO	J:155856
Biological Process	GO:0051248	negative regulation of protein metabolic process	ISO	J:155856
Biological Process	GO:0001890	placenta development	IMP	J:58075
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:1904031	positive regulation of cyclin-dependent protein kinase activity	IMP	J:259130
Biological Process	GO:1904031	positive regulation of cyclin-dependent protein kinase activity	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:259119
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:155856
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:259119
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0006457	protein folding	IMP	J:276383
Biological Process	GO:0006457	protein folding	IBA	J:265628
Biological Process	GO:0050821	protein stabilization	IBA	J:265628
Biological Process	GO:0032880	regulation of protein localization	IMP	J:259119
Biological Process	GO:0010033	response to organic substance	IDA	J:146128