GO Annotations Graph

• Symbol: Hsp90aa1
• Name: heat shock protein 90, alpha (cytosolic), class A member 1
• ID: MGI:96250

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IBA	J:265628
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0002135	CTP binding	ISO	J:155856
Molecular Function	GO:0032564	dATP binding	ISO	J:155856
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0097718	disordered domain specific binding	IBA	J:265628
Molecular Function	GO:0070182	DNA polymerase binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0051020	GTPase binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:84681
Molecular Function	GO:0003729	mRNA binding	ISO	J:155856
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	ISO	J:164563
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	IDA	J:113936
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:137614
Molecular Function	GO:0005515	protein binding	IPI	J:259136
Molecular Function	GO:0005515	protein binding	IPI	J:113936
Molecular Function	GO:0005515	protein binding	IPI	J:113936
Molecular Function	GO:0005515	protein binding	IPI	J:247279
Molecular Function	GO:0005515	protein binding	IPI	J:136214
Molecular Function	GO:0005515	protein binding	IPI	J:272245
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:185047
Molecular Function	GO:0005515	protein binding	IPI	J:84681
Molecular Function	GO:0005515	protein binding	IPI	J:272245
Molecular Function	GO:0005515	protein binding	IPI	J:197112
Molecular Function	GO:0005515	protein binding	IPI	J:84681
Molecular Function	GO:0044183	protein folding chaperone	IMP	J:276383
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0051022	Rho GDP-dissociation inhibitor binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0017098	sulfonylurea receptor binding	ISO	J:155856
Molecular Function	GO:0048156	tau protein binding	ISO	J:155856
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0030911	TPR domain binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	TAS	J:113936
Molecular Function	GO:0051082	unfolded protein binding	IBA	J:265628
Molecular Function	GO:0002134	UTP binding	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0044295	axonal growth cone	IDA	J:259119
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:276383
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:247279
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:125489
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	J:113936
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646345
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9646359
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:129009
Cellular Component	GO:0044294	dendritic growth cone	IDA	J:259119
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:39331
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043209	myelin sheath	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:259119
Cellular Component	GO:0043025	neuronal cell body	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:259119
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:276383
Cellular Component	GO:0032991	protein-containing complex	IBA	J:265628
Cellular Component	GO:0036126	sperm flagellum	ISO	J:155856
Cellular Component	GO:0097226	sperm mitochondrial sheath	ISO	J:155856
Cellular Component	GO:0097524	sperm plasma membrane	ISO	J:155856
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0048675	axon extension	IMP	J:259119
Biological Process	GO:0034605	cellular response to heat	IMP	J:276383
Biological Process	GO:0034605	cellular response to heat	IBA	J:265628
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0021955	central nervous system neuron axonogenesis	IMP	J:259119
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	ISO	J:164563
Biological Process	GO:0030010	establishment of cell polarity	IMP	J:259119
Biological Process	GO:0001764	neuron migration	ISO	J:155856
Biological Process	GO:0006809	nitric oxide biosynthetic process	TAS	J:113936
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:0045585	positive regulation of cytotoxic T cell differentiation	TAS	J:113936
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IDA	J:113936
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:259119
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:259119
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0032273	positive regulation of protein polymerization	ISO	J:164563
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0006457	protein folding	IMP	J:276383
Biological Process	GO:0006457	protein folding	IBA	J:265628
Biological Process	GO:0045040	protein insertion into mitochondrial outer membrane	ISO	J:164563
Biological Process	GO:0042026	protein refolding	TAS	J:113936
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IBA	J:265628
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	IMP	J:259119
Biological Process	GO:0031396	regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	TAS	J:113936
Biological Process	GO:1905323	telomerase holoenzyme complex assembly	ISO	J:164563
Biological Process	GO:0007004	telomere maintenance via telomerase	ISO	J:164563