GO Annotations Graph

• Symbol: Htr1a
• Name: 5-hydroxytryptamine (serotonin) receptor 1A
• ID: MGI:96273

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IMP	J:51280
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:155856
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IDA	J:16036
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:155856
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0090722	receptor-receptor interaction	ISO	J:164563
Molecular Function	GO:0051378	serotonin binding	ISO	J:155856
Molecular Function	GO:0051378	serotonin binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0043203	axon hillock	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007610	behavior	IEA	J:60000
Biological Process	GO:0001662	behavioral fear response	IMP	J:51280
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0035640	exploration behavior	IMP	J:51280
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	IDA	J:16036
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	IMP	J:144307
Biological Process	GO:0014053	negative regulation of gamma-aminobutyric acid secretion	ISO	J:155856
Biological Process	GO:0097114	NMDA glutamate receptor clustering	ISO	J:155856
Biological Process	GO:0031117	positive regulation of microtubule depolymerization	ISO	J:155856
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0050795	regulation of behavior	IEA	J:72247
Biological Process	GO:0042053	regulation of dopamine metabolic process	IMP	J:65662
Biological Process	GO:0060259	regulation of feeding behavior	ISO	J:155856
Biological Process	GO:0046883	regulation of hormone secretion	IEA	J:72247
Biological Process	GO:0014062	regulation of serotonin secretion	IMP	J:51280
Biological Process	GO:0019229	regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0042428	serotonin metabolic process	IMP	J:65662
Biological Process	GO:0007210	serotonin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007210	serotonin receptor signaling pathway	IMP	J:51280
Biological Process	GO:0007165	signal transduction	IEA	J:60000