GO Annotations Graph

• Symbol: Htr1b
• Name: 5-hydroxytryptamine (serotonin) receptor 1B
• ID: MGI:96274

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IDA	J:163130
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:155856
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IDA	MGI:MGI:64075
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0051378	serotonin binding	IDA	J:163130
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO	J:155856
Cellular Component	GO:0044305	calyx of Held	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:163130
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	IDA	J:163130
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:163130
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:54961
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:54961
Cellular Component	GO:0099154	serotonergic synapse	IDA	J:54961
Cellular Component	GO:0099154	serotonergic synapse	IDA	J:54961
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	MGI:MGI:64075
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007610	behavior	IEA	J:60000
Biological Process	GO:0046849	bone remodeling	IGI	J:146078
Biological Process	GO:0046849	bone remodeling	IGI	J:146078
Biological Process	GO:0071312	cellular response to alkaloid	ISO	J:164563
Biological Process	GO:0071502	cellular response to temperature stimulus	IDA	J:163130
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0007268	chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0042756	drinking behavior	ISO	J:155856
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0002031	G protein-coupled receptor internalization	IDA	J:163130
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0014053	negative regulation of gamma-aminobutyric acid secretion	ISO	J:155856
Biological Process	GO:0014063	negative regulation of serotonin secretion	IMP	J:43716
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IMP	J:163130
Biological Process	GO:0050795	regulation of behavior	IEA	J:72247
Biological Process	GO:0014059	regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0042220	response to cocaine	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0009636	response to toxic substance	IDA	MGI:MGI:64075
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0042310	vasoconstriction	IEA	J:72247