GO Annotations Graph

• Symbol: Iapp
• Name: islet amyloid polypeptide
• ID: MGI:96382

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005179	hormone activity	IEA	J:72247
Molecular Function	GO:0005179	hormone activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186609
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:126780
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0097647	amylin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0097647	amylin receptor signaling pathway	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0045453	bone resorption	IMP	J:88964
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0045779	negative regulation of bone resorption	IMP	J:88964
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IMP	J:88964
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IMP	J:88964
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IGI	J:88964
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IGI	J:88964
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:88964
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:88964
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0019233	sensory perception of pain	IMP	J:51556