GO Annotations Graph

• Symbol: Ide
• Name: insulin degrading enzyme
• ID: MGI:96412

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:155856
Molecular Function	GO:0031626	beta-endorphin binding	ISO	J:155856
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:237352
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043559	insulin binding	ISO	J:164563
Molecular Function	GO:0043559	insulin binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:155856
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0042277	peptide binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0031597	cytosolic proteasome complex	ISO	J:155856
Cellular Component	GO:0031904	endosome lumen	IDA	J:237352
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	IMP	J:268009
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005782	peroxisomal matrix	ISO	J:155856
Cellular Component	GO:0005782	peroxisomal matrix	IBA	J:265628
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0097242	amyloid-beta clearance	ISO	J:164563
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:268009
Biological Process	GO:0097242	amyloid-beta clearance	ISO	J:155856
Biological Process	GO:0097242	amyloid-beta clearance	IDA	J:243822
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	ISO	J:155856
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	ISO	J:164563
Biological Process	GO:0050435	amyloid-beta metabolic process	ISO	J:164563
Biological Process	GO:0050435	amyloid-beta metabolic process	ISO	J:155856
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO	J:164563
Biological Process	GO:0010815	bradykinin catabolic process	ISO	J:164563
Biological Process	GO:0042447	hormone catabolic process	ISO	J:155856
Biological Process	GO:0042447	hormone catabolic process	ISO	J:164563
Biological Process	GO:1901143	insulin catabolic process	IMP	J:213208
Biological Process	GO:1901143	insulin catabolic process	ISO	J:164563
Biological Process	GO:1901143	insulin catabolic process	IDA	J:237352
Biological Process	GO:1901142	insulin metabolic process	ISO	J:164563
Biological Process	GO:0038020	insulin receptor recycling	IDA	J:237352
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:155856
Biological Process	GO:0043171	peptide catabolic process	ISO	J:164563
Biological Process	GO:0043171	peptide catabolic process	IBA	J:265628
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	IMP	J:268009
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:155856
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IBA	J:265628
Biological Process	GO:1903715	regulation of aerobic respiration	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	IDA	J:243822
Biological Process	GO:0010992	ubiquitin recycling	ISO	J:164563