GO Annotations Graph

• Symbol: Ido1
• Name: indoleamine 2,3-dioxygenase 1
• ID: MGI:96416

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016597	amino acid binding	ISO	J:155856
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0020037	heme binding	IEA	J:72247
Molecular Function	GO:0033754	indoleamine 2,3-dioxygenase activity	ISO	J:155856
Molecular Function	GO:0033754	indoleamine 2,3-dioxygenase activity	ISO	J:164563
Molecular Function	GO:0033754	indoleamine 2,3-dioxygenase activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0019825	oxygen binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:176469
Molecular Function	GO:0004833	tryptophan 2,3-dioxygenase activity	IBA	J:265628
Molecular Function	GO:0004833	tryptophan 2,3-dioxygenase activity	IDA	J:73851
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:160505
Cellular Component	GO:0005737	cytoplasm	IDA	J:123879
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030485	smooth muscle contractile fiber	IDA	J:160505
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:160505
Biological Process	GO:0034354	'de novo' NAD biosynthetic process from tryptophan	IBA	J:265628
Biological Process	GO:0002534	cytokine production involved in inflammatory response	IMP	J:146236
Biological Process	GO:0006952	defense response	TAS	J:72138
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:148645
Biological Process	GO:0032613	interleukin-10 production	IMP	J:146236
Biological Process	GO:0032615	interleukin-12 production	IMP	J:146236
Biological Process	GO:0034276	kynurenic acid biosynthetic process	IMP	J:146236
Biological Process	GO:0033555	multicellular organismal response to stress	IMP	J:146234
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	IMP	J:132719
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:146236
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	IMP	J:132719
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:132719
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:148645
Biological Process	GO:0002678	positive regulation of chronic inflammatory response	IMP	J:134645
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:146236
Biological Process	GO:0070234	positive regulation of T cell apoptotic process	ISO	J:164563
Biological Process	GO:0002666	positive regulation of T cell tolerance induction	IMP	J:49473
Biological Process	GO:0002830	positive regulation of type 2 immune response	IMP	J:134645
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:146236
Biological Process	GO:0036269	swimming behavior	IMP	J:146234
Biological Process	GO:0042098	T cell proliferation	IMP	J:132719
Biological Process	GO:0006569	tryptophan catabolic process	IEA	J:60000
Biological Process	GO:0019441	tryptophan catabolic process to kynurenine	ISO	J:155856
Biological Process	GO:0019441	tryptophan catabolic process to kynurenine	IBA	J:265628
Biological Process	GO:0019441	tryptophan catabolic process to kynurenine	IDA	J:72138
Biological Process	GO:0019441	tryptophan catabolic process to kynurenine	IDA	J:73851