GO Annotations Graph

• Symbol: Igf2
• Name: insulin-like growth factor 2
• ID: MGI:96434

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	IEA	J:60000
Molecular Function	GO:0005179	hormone activity	IEA	J:72247
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	IPI	J:86296
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:156975
Molecular Function	GO:0005515	protein binding	IPI	J:86296
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IMP	J:158405
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IBA	J:265628
Molecular Function	GO:0048018	receptor ligand activity	IMP	J:158405
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:42756
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:288213
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IGI	J:42756
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IDA	J:288213
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:138783
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:79280
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0001892	embryonic placenta development	IMP	J:77386
Biological Process	GO:0060669	embryonic placenta morphogenesis	IMP	J:243423
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:79280
Biological Process	GO:0006006	glucose metabolic process	IEA	J:60000
Biological Process	GO:0001701	in utero embryonic development	IMP	J:243423
Biological Process	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	IMP	J:158405
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:42756
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:288213
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	IMP	J:296123
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:243401
Biological Process	GO:0001503	ossification	IEA	J:60000
Biological Process	GO:0001649	osteoblast differentiation	IEP	J:143682
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:155856
Biological Process	GO:0043085	positive regulation of catalytic activity	IMP	J:158405
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2000467	positive regulation of glycogen (starch) synthase activity	IMP	J:158405
Biological Process	GO:2000467	positive regulation of glycogen (starch) synthase activity	IBA	J:265628
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	IMP	J:158405
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	IMP	J:158405
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:41236
Biological Process	GO:0046622	positive regulation of organ growth	IMP	J:265506
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:158405
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IBA	J:265628
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:158405
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	IMP	J:265506
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:138783
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:155856
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	IBA	J:265628
Biological Process	GO:0051147	regulation of muscle cell differentiation	IMP	J:243401
Biological Process	GO:0051147	regulation of muscle cell differentiation	IBA	J:265628
Biological Process	GO:0035094	response to nicotine	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0060720	spongiotrophoblast cell proliferation	IMP	J:184520
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:138783