GO Annotations Graph

• Symbol: Igfbp4
• Name: insulin-like growth factor binding protein 4
• ID: MGI:96439

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019838	growth factor binding	IEA	J:60000
Molecular Function	GO:0005520	insulin-like growth factor binding	IPI	J:3735
Molecular Function	GO:0031994	insulin-like growth factor I binding	IBA	J:265628
Molecular Function	GO:0031995	insulin-like growth factor II binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:137648
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:16863
Cellular Component	GO:0005615	extracellular space	IDA	J:3735
Biological Process	GO:0000165	MAPK cascade	IGI	J:112029
Biological Process	GO:0000165	MAPK cascade	IGI	J:112029
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	IGI	J:112029
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	IGI	J:112029
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGI	J:112029
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGI	J:112029
Biological Process	GO:0001558	regulation of cell growth	IGI	J:112029
Biological Process	GO:0001558	regulation of cell growth	IGI	J:112029
Biological Process	GO:0010906	regulation of glucose metabolic process	IGI	J:112029
Biological Process	GO:0010906	regulation of glucose metabolic process	IGI	J:112029
Biological Process	GO:0040008	regulation of growth	IGI	J:112029
Biological Process	GO:0040008	regulation of growth	IGI	J:112029
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:112029
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:112029