GO Annotations Graph

• Symbol: Cd74
• Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
• ID: MGI:96534

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0042609	CD4 receptor binding	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	IDA	J:131317
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0004896	cytokine receptor activity	ISO	J:164563
Molecular Function	GO:0004896	cytokine receptor activity	IMP	J:156237
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0035718	macrophage migration inhibitory factor binding	ISO	J:164563
Molecular Function	GO:0035718	macrophage migration inhibitory factor binding	IBA	J:265628
Molecular Function	GO:0042289	MHC class II protein binding	IPI	J:88528
Molecular Function	GO:0042289	MHC class II protein binding	IBA	J:265628
Molecular Function	GO:0042658	MHC class II protein binding, via antigen binding groove	ISO	J:164563
Molecular Function	GO:0023026	MHC class II protein complex binding	ISO	J:164563
Molecular Function	GO:0050998	nitric-oxide synthase binding	IPI	J:169889
Molecular Function	GO:0005515	protein binding	IPI	J:131317
Molecular Function	GO:0005515	protein binding	IPI	J:115604
Molecular Function	GO:0005515	protein binding	IPI	J:271359
Molecular Function	GO:0005515	protein binding	IPI	J:89707
Molecular Function	GO:0005515	protein binding	IPI	J:88528
Molecular Function	GO:0044183	protein folding chaperone	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:88531
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:4119
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:152384
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92721
Cellular Component	GO:0005615	extracellular space	IDA	J:271359
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:88531
Cellular Component	GO:0005770	late endosome	IDA	J:115604
Cellular Component	GO:0005770	late endosome	IDA	J:92692
Cellular Component	GO:0005764	lysosome	IDA	J:115604
Cellular Component	GO:0005764	lysosome	IDA	J:88531
Cellular Component	GO:0005764	lysosome	IDA	J:92692
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	IDA	J:131317
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	ISO	J:164563
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	IDA	J:156237
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:88528
Cellular Component	GO:0005771	multivesicular body	IDA	J:88531
Cellular Component	GO:0035693	NOS2-CD74 complex	IDA	J:169889
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:88531
Cellular Component	GO:0005886	plasma membrane	IDA	J:65917
Cellular Component	GO:0005886	plasma membrane	TAS	J:4119
Cellular Component	GO:0005886	plasma membrane	IMP	J:65918
Cellular Component	GO:0005886	plasma membrane	IMP	J:65917
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005773	vacuole	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019882	antigen processing and presentation	IBA	J:265628
Biological Process	GO:0019882	antigen processing and presentation	IDA	J:8106
Biological Process	GO:0019882	antigen processing and presentation	IDA	J:88528
Biological Process	GO:0019882	antigen processing and presentation	IMP	J:88532
Biological Process	GO:0019882	antigen processing and presentation	IDA	J:89707
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP	J:31624
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP	J:4119
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	IMP	J:4119
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	IDA	J:88528
Biological Process	GO:0006952	defense response	IMP	J:65918
Biological Process	GO:0006952	defense response	IMP	J:65917
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0016064	immunoglobulin mediated immune response	IMP	J:4119
Biological Process	GO:0006886	intracellular protein transport	IMP	J:4119
Biological Process	GO:0006886	intracellular protein transport	IDA	J:92692
Biological Process	GO:0006886	intracellular protein transport	IDA	J:89707
Biological Process	GO:0035691	macrophage migration inhibitory factor signaling pathway	IDA	J:169979
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP	J:114878
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IBA	J:265628
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	J:114878
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:164563
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA	J:265628
Biological Process	GO:0002906	negative regulation of mature B cell apoptotic process	IMP	J:131317
Biological Process	GO:0002792	negative regulation of peptide secretion	ISO	J:164563
Biological Process	GO:0045581	negative regulation of T cell differentiation	IMP	J:4119
Biological Process	GO:0046597	negative regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0045060	negative thymic T cell selection	IMP	J:4119
Biological Process	GO:0002821	positive regulation of adaptive immune response	NAS	J:131317
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA	J:169979
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	IMP	J:156237
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	IDA	J:169889
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:156237
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045089	positive regulation of innate immune response	IC	J:169979
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:169979
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IBA	J:265628
Biological Process	GO:2000448	positive regulation of macrophage migration inhibitory factor signaling pathway	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0045657	positive regulation of monocyte differentiation	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	IDA	J:169979
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:114878
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IBA	J:265628
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:31624
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:88532
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:4119
Biological Process	GO:0002830	positive regulation of type 2 immune response	IMP	J:74460
Biological Process	GO:0002830	positive regulation of type 2 immune response	IBA	J:265628
Biological Process	GO:0046598	positive regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0045059	positive thymic T cell selection	IMP	J:31624
Biological Process	GO:0045059	positive thymic T cell selection	IMP	J:4119
Biological Process	GO:0045059	positive thymic T cell selection	IMP	J:88532
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:271359
Biological Process	GO:0050821	protein stabilization	IMP	J:115604
Biological Process	GO:0070206	protein trimerization	IEA	J:72247
Biological Process	GO:0065003	protein-containing complex assembly	IDA	J:88528
Biological Process	GO:0034341	response to type II interferon	IDA	J:297334
Biological Process	GO:0034341	response to type II interferon	ISO	J:164563
Biological Process	GO:0002286	T cell activation involved in immune response	IBA	J:265628