GO Annotations Graph

• Symbol: Il12b
• Name: interleukin 12b
• ID: MGI:96540

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:65439
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0005126	cytokine receptor binding	IPI	J:65966
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:84402
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	ISO	J:164563
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	ISO	J:155856
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	IPI	J:91804
Molecular Function	GO:0045519	interleukin-23 receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:65966
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:164687
Cellular Component	GO:0005737	cytoplasm	IDA	J:73394
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-8950489
Cellular Component	GO:0031904	endosome lumen	TAS	Reactome:R-MMU-8950510
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8950442
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8950612
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8950679
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9006466
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:314396
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:84402
Cellular Component	GO:0005615	extracellular space	IDA	J:208236
Cellular Component	GO:0005615	extracellular space	IDA	J:96035
Cellular Component	GO:0005615	extracellular space	IDA	J:102933
Cellular Component	GO:0005615	extracellular space	IDA	J:91939
Cellular Component	GO:0005615	extracellular space	IDA	J:91804
Cellular Component	GO:0005615	extracellular space	IDA	J:84679
Cellular Component	GO:0005615	extracellular space	IDA	J:143981
Cellular Component	GO:0005615	extracellular space	IDA	J:111178
Cellular Component	GO:0005615	extracellular space	IDA	J:15406
Cellular Component	GO:0005796	Golgi lumen	TAS	Reactome:R-MMU-8950489
Cellular Component	GO:0005796	Golgi lumen	TAS	Reactome:R-MMU-8950510
Cellular Component	GO:0043514	interleukin-12 complex	ISO	J:164563
Cellular Component	GO:0043514	interleukin-12 complex	ISO	J:155856
Cellular Component	GO:0043514	interleukin-12 complex	ISO	J:164563
Cellular Component	GO:0043514	interleukin-12 complex	IGI	J:15406
Cellular Component	GO:0043514	interleukin-12 complex	IDA	J:91804
Cellular Component	GO:0042022	interleukin-12 receptor complex	NAS	J:37050
Cellular Component	GO:0070743	interleukin-23 complex	ISO	J:164563
Cellular Component	GO:0070743	interleukin-23 complex	ISO	J:164563
Cellular Component	GO:0070743	interleukin-23 complex	IDA	J:65966
Cellular Component	GO:0070743	interleukin-23 complex	IPI	J:65966
Cellular Component	GO:0072536	interleukin-23 receptor complex	NAS	J:76845
Cellular Component	GO:0016020	membrane	IEA	J:72247
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IGI	J:98417
Biological Process	GO:0008283	cell population proliferation	IDA	J:98417
Biological Process	GO:0008283	cell population proliferation	IGI	J:98417
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:84402
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:173334
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:155210
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:155210
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0042832	defense response to protozoan	IGI	J:111178
Biological Process	GO:0042832	defense response to protozoan	IDA	J:142066
Biological Process	GO:0042832	defense response to protozoan	IMP	J:111178
Biological Process	GO:0051607	defense response to virus	IDA	J:143981
Biological Process	GO:0006955	immune response	NAS	J:319975
Biological Process	GO:0016064	immunoglobulin mediated immune response	IBA	J:265628
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0030101	natural killer cell activation	ISO	J:164563
Biological Process	GO:0002323	natural killer cell activation involved in immune response	ISO	J:155856
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IMP	J:113450
Biological Process	GO:0032693	negative regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032700	negative regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IDA	J:87643
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032740	positive regulation of interleukin-17 production	NAS	J:320271
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	ISO	J:164563
Biological Process	GO:0032946	positive regulation of mononuclear cell proliferation	ISO	J:164563
Biological Process	GO:0032816	positive regulation of natural killer cell activation	ISO	J:164563
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO	J:164563
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:0051135	positive regulation of NK T cell activation	ISO	J:164563
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	NAS	J:319975
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	ISO	J:164563
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IDA	J:87643
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:65966
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:65439
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	ISO	J:164563
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IDA	J:87643
Biological Process	GO:2000318	positive regulation of T-helper 17 type immune response	NAS	J:320271
Biological Process	GO:2000318	positive regulation of T-helper 17 type immune response	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:113450
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:111178
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:173261
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:98417
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:98417
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0010033	response to organic substance	IDA	J:146128
Biological Process	GO:0010224	response to UV-B	ISO	J:164563
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0042098	T cell proliferation	IDA	J:65439
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IGI	J:98417
Biological Process	GO:0035744	T-helper 1 cell cytokine production	IGI	J:98417
Biological Process	GO:0042093	T-helper cell differentiation	ISO	J:164563
Biological Process	GO:0032609	type II interferon production	IGI	J:111178
Biological Process	GO:0032609	type II interferon production	IDA	J:173261