GO Annotations Graph

• Symbol: Il13
• Name: interleukin 13
• ID: MGI:96541

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005126	cytokine receptor binding	IEA	J:72247
Molecular Function	GO:0005144	interleukin-13 receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:202854
Molecular Function	GO:0005515	protein binding	IPI	J:236976
Cellular Component	GO:0005737	cytoplasm	IDA	J:73394
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141227
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:151963
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:91286
Cellular Component	GO:0005615	extracellular space	IDA	J:140498
Cellular Component	GO:0005615	extracellular space	IDA	J:113450
Cellular Component	GO:0005615	extracellular space	IDA	J:143168
Cellular Component	GO:0005615	extracellular space	IDA	J:172134
Cellular Component	GO:0005615	extracellular space	IDA	J:91939
Cellular Component	GO:0005615	extracellular space	IDA	J:117165
Biological Process	GO:0071345	cellular response to cytokine stimulus	IDA	J:151963
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IMP	J:98708
Biological Process	GO:0042116	macrophage activation	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0033861	negative regulation of NAD(P)H oxidase activity	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0071635	negative regulation of transforming growth factor beta production	ISO	J:155856
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:214452
Biological Process	GO:0032723	positive regulation of connective tissue growth factor production	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:155856
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IGI	J:100883
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:100883
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:157197
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IMP	J:100883
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IGI	J:100883
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	ISO	J:155856
Biological Process	GO:2000231	positive regulation of pancreatic stellate cell proliferation	ISO	J:155856
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:155856
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0010155	regulation of proton transport	ISO	J:155856
Biological Process	GO:0035094	response to nicotine	ISO	J:155856