Il1b GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Il1b
interleukin 1 beta
MGI:96543

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:93342
Molecular Function	GO:0005125	cytokine activity	ISO	J:73065
Molecular Function	GO:0005125	cytokine activity	IDA	J:85159
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005149	interleukin-1 receptor binding	IEA	J:72247
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:213232
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:67213
Cellular Component	GO:0005615	extracellular space	IDA	J:99000
Cellular Component	GO:0005615	extracellular space	IDA	J:295244
Cellular Component	GO:0005615	extracellular space	IDA	J:208236
Cellular Component	GO:0005615	extracellular space	IDA	J:110582
Cellular Component	GO:0005615	extracellular space	IDA	J:66835
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0030141	secretory granule	IDA	J:110582
Cellular Component	GO:0031982	vesicle	IDA	J:99000
Biological Process	GO:0048143	astrocyte activation	IDA	J:259461
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:269278
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:145965
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:145965
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:115619
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:115619
Biological Process	GO:0001660	fever generation	IEA	J:60000
Biological Process	GO:0030213	hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0032635	interleukin-6 production	IDA	J:98417
Biological Process	GO:0032635	interleukin-6 production	IDA	J:93342
Biological Process	GO:0007254	JNK cascade	IDA	J:102721
Biological Process	GO:0007254	JNK cascade	IGI	J:102721
Biological Process	GO:0050900	leukocyte migration	IDA	J:88722
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:98417
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0070487	monocyte aggregation	ISO	J:164563
Biological Process	GO:0070164	negative regulation of adiponectin secretion	IDA	J:143678
Biological Process	GO:2000173	negative regulation of branching morphogenesis of a nerve	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:1903597	negative regulation of gap junction assembly	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010829	negative regulation of glucose transmembrane transport	IDA	J:143678
Biological Process	GO:0014050	negative regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IDA	J:143678
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0045833	negative regulation of lipid metabolic process	IDA	J:143678
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IDA	J:143678
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0050768	negative regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0050805	negative regulation of synaptic transmission	IMP	J:241477
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IDA	J:85159
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:82394
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	ISO	J:155856
Biological Process	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:85159
Biological Process	GO:0045917	positive regulation of complement activation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0031622	positive regulation of fever generation	IDA	J:155398
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:151963
Biological Process	GO:0045687	positive regulation of glial cell differentiation	ISO	J:155856
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:164563
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	ISO	J:155856
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IBA	J:265628
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:161934
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:152781
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:73065
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:85159
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:93342
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:241477
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:102721
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:102721
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0050996	positive regulation of lipid catabolic process	IDA	J:143678
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	ISO	J:164563
Biological Process	GO:0035505	positive regulation of myosin light chain kinase activity	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	IGI	J:241477
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IDA	J:155398
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:1902680	positive regulation of RNA biosynthetic process	ISO	J:164563
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:152781
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:82394
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0050691	regulation of defense response to virus by host	IDA	J:213232
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0050767	regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IDA	J:228116
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IBA	J:265628
Biological Process	GO:0033198	response to ATP	IDA	J:122152
Biological Process	GO:0033198	response to ATP	IMP	J:136350
Biological Process	GO:0033198	response to ATP	IDA	J:99000
Biological Process	GO:0033198	response to ATP	IDA	J:136350
Biological Process	GO:0009743	response to carbohydrate	IDA	J:122152
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:110582
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:136350
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:136350
Biological Process	GO:0030730	sequestering of triglyceride	ISO	J:164563
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0010573	vascular endothelial growth factor production	ISO	J:164563

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