GO Annotations Graph

• Symbol: Casp1
• Name: caspase 1
• ID: MGI:96544

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050700	CARD domain binding	ISO	J:164563
Molecular Function	GO:0089720	caspase binding	IBA	J:265628
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	ISO	J:164563
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	IDA	J:296118
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:326901
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:306581
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:326897
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:193599
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:296118
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:296118
Molecular Function	GO:0008233	peptidase activity	IDA	J:136350
Molecular Function	GO:0005515	protein binding	IPI	J:113677
Molecular Function	GO:0005515	protein binding	IPI	J:186690
Molecular Function	GO:0005515	protein binding	IPI	J:273511
Molecular Function	GO:0005515	protein binding	IPI	J:113808
Molecular Function	GO:0005515	protein binding	IPI	J:245276
Molecular Function	GO:0005515	protein binding	IPI	J:189256
Molecular Function	GO:0005515	protein binding	IPI	J:245242
Molecular Function	GO:0005515	protein binding	IPI	J:91292
Molecular Function	GO:0005515	protein binding	IPI	J:72719
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Cellular Component	GO:0097169	AIM2 inflammasome complex	ISO	J:164563
Cellular Component	GO:0097169	AIM2 inflammasome complex	IBA	J:265628
Cellular Component	GO:0061702	canonical inflammasome complex	ISO	J:164563
Cellular Component	GO:0008303	caspase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	NAS	J:319953
Cellular Component	GO:0005737	cytoplasm	NAS	J:320796
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	NAS	J:158968
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:306581
Cellular Component	GO:0005737	cytoplasm	TAS	J:91292
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-877388
Cellular Component	GO:0005829	cytosol	IDA	J:326897
Cellular Component	GO:0005576	extracellular region	IDA	J:91292
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0072557	IPAF inflammasome complex	IDA	J:176197
Cellular Component	GO:0072557	IPAF inflammasome complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	NAS	J:263129
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0072558	NLRP1 inflammasome complex	ISO	J:164563
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NAS	J:320796
Cellular Component	GO:0072559	NLRP3 inflammasome complex	ISO	J:164563
Cellular Component	GO:0072559	NLRP3 inflammasome complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0097179	protease inhibitor complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	IDA	J:205029
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	IDA	J:236847
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	IDA	J:293308
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:145965
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0140447	cytokine precursor processing	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IDA	J:326897
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:284724
Biological Process	GO:0051607	defense response to virus	NAS	J:158968
Biological Process	GO:0032610	interleukin-1 alpha production	IMP	J:136350
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:136350
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:145965
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:136350
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060081	membrane hyperpolarization	IMP	J:192731
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0051882	mitochondrial depolarization	IMP	J:192731
Biological Process	GO:0007520	myoblast fusion	ISO	J:155856
Biological Process	GO:0007231	osmosensory signaling pathway	NAS	J:187661
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:320796
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	IDA	J:138812
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:158968
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:319676
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:320140
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	IDA	J:306581
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:131152
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:320796
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:158968
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:259950
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:257673
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:138812
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:296118
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:296118
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:296118
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	IMP	J:136350
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:259950
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:257673
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NAS	J:320796
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:138812
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:306581
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:136350
Biological Process	GO:0032741	positive regulation of interleukin-18 production	ISO	J:164563
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:136350
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IDA	J:88212
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	IDA	J:88212
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0097300	programmed necrotic cell death	IDA	J:99748
Biological Process	GO:0016540	protein autoprocessing	IDA	J:306581
Biological Process	GO:0016540	protein autoprocessing	ISO	J:164563
Biological Process	GO:0051604	protein maturation	ISO	J:164563
Biological Process	GO:0051604	protein maturation	IDA	J:326897
Biological Process	GO:0051604	protein maturation	IDA	J:296118
Biological Process	GO:0051604	protein maturation	IDA	J:296118
Biological Process	GO:0051604	protein maturation	IDA	J:296118
Biological Process	GO:0051604	protein maturation	IDA	J:296118
Biological Process	GO:0051604	protein maturation	IDA	J:296118
Biological Process	GO:0051604	protein maturation	IDA	J:296118
Biological Process	GO:0016485	protein processing	IMP	J:122152
Biological Process	GO:0016485	protein processing	IMP	J:88212
Biological Process	GO:0016485	protein processing	IDA	J:91292
Biological Process	GO:0016485	protein processing	IDA	J:66835
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	NAS	J:320796
Biological Process	GO:0070269	pyroptosis	IDA	J:306581
Biological Process	GO:0070269	pyroptosis	NAS	J:319676
Biological Process	GO:0070269	pyroptosis	NAS	J:229325
Biological Process	GO:0070269	pyroptosis	IDA	J:229325
Biological Process	GO:0070269	pyroptosis	NAS	J:158968
Biological Process	GO:0070269	pyroptosis	IMP	J:193522
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0010506	regulation of autophagy	IMP	J:212020
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:181354
Biological Process	GO:0033198	response to ATP	IMP	J:136350
Biological Process	GO:0009617	response to bacterium	IMP	J:212020
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	IMP	J:88212
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:122152
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0140448	signaling receptor ligand precursor processing	ISO	J:164563
Biological Process	GO:1901998	toxin transport	IMP	J:197389