GO Annotations Graph

• Symbol: Il1rn
• Name: interleukin 1 receptor antagonist
• ID: MGI:96547

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:72247
Molecular Function	GO:0005152	interleukin-1 receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0005152	interleukin-1 receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0005152	interleukin-1 receptor antagonist activity	IBA	J:265628
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:155856
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:164563
Molecular Function	GO:0045352	interleukin-1 type I receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0045353	interleukin-1 type II receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0005150	interleukin-1, type I receptor binding	ISO	J:164563
Molecular Function	GO:0005151	interleukin-1, type II receptor binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IDA	J:91940
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0031982	vesicle	IDA	J:91940
Biological Process	GO:0006953	acute-phase response	ISO	J:164563
Biological Process	GO:0001660	fever generation	ISO	J:155856
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IEA	J:72247
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IBA	J:265628
Biological Process	GO:0030073	insulin secretion	IMP	J:85532
Biological Process	GO:0006629	lipid metabolic process	IMP	J:85532
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0014050	negative regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0045837	negative regulation of membrane potential	ISO	J:155856
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:164563
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856