GO Annotations Graph

• Symbol: Il4
• Name: interleukin 4
• ID: MGI:96556

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:76115
Molecular Function	GO:0005125	cytokine activity	IDA	J:88533
Molecular Function	GO:0005125	cytokine activity	IDA	J:98326
Molecular Function	GO:0005125	cytokine activity	IDA	J:64603
Molecular Function	GO:0005125	cytokine activity	IDA	J:1013
Molecular Function	GO:0005125	cytokine activity	IDA	J:112035
Molecular Function	GO:0005126	cytokine receptor binding	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0005136	interleukin-4 receptor binding	IEA	J:72247
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:151963
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:160369
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:165919
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:168252
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:175944
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:147177
Cellular Component	GO:0005615	extracellular space	IDA	J:172134
Cellular Component	GO:0005615	extracellular space	IDA	J:140498
Cellular Component	GO:0005615	extracellular space	IDA	J:143981
Cellular Component	GO:0005615	extracellular space	IDA	J:75400
Cellular Component	GO:0005615	extracellular space	IDA	J:116306
Cellular Component	GO:0005615	extracellular space	IDA	J:91286
Cellular Component	GO:0005615	extracellular space	IDA	J:117165
Cellular Component	GO:0005615	extracellular space	IDA	J:65439
Biological Process	GO:0050798	activated T cell proliferation	IDA	J:98326
Biological Process	GO:0050798	activated T cell proliferation	IDA	J:112035
Biological Process	GO:0042976	activation of Janus kinase activity	ISO	J:164563
Biological Process	GO:0042976	activation of Janus kinase activity	IBA	J:265628
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0042113	B cell activation	IDA	J:30239
Biological Process	GO:0031296	B cell costimulation	IBA	J:265628
Biological Process	GO:0031296	B cell costimulation	IDA	J:141184
Biological Process	GO:0042100	B cell proliferation	IDA	J:106733
Biological Process	GO:0042100	B cell proliferation	IDA	J:64603
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:76258
Biological Process	GO:0042832	defense response to protozoan	IMP	J:20463
Biological Process	GO:0097028	dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:56164
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:78230
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002227	innate immune response in mucosa	IDA	J:172916
Biological Process	GO:0002227	innate immune response in mucosa	IBA	J:265628
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048289	isotype switching to IgE isotypes	IDA	J:88910
Biological Process	GO:0048291	isotype switching to IgG isotypes	IDA	J:88910
Biological Process	GO:0042116	macrophage activation	ISO	J:164563
Biological Process	GO:0045342	MHC class II biosynthetic process	IDA	J:76115
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0001774	microglial cell activation	IBA	J:265628
Biological Process	GO:0043011	myeloid dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IBA	J:265628
Biological Process	GO:0002674	negative regulation of acute inflammatory response	ISO	J:155856
Biological Process	GO:0002674	negative regulation of acute inflammatory response	IBA	J:265628
Biological Process	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	ISO	J:155856
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	IBA	J:265628
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	ISO	J:164563
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	IBA	J:265628
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IBA	J:265628
Biological Process	GO:0010633	negative regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0010633	negative regulation of epithelial cell migration	IBA	J:265628
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IDA	J:56164
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0043031	negative regulation of macrophage activation	ISO	J:155856
Biological Process	GO:0043031	negative regulation of macrophage activation	IBA	J:265628
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IDA	J:85571
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IDA	J:145836
Biological Process	GO:0050868	negative regulation of T cell activation	IDA	J:143168
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IBA	J:265628
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IDA	J:141227
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IDA	J:274783
Biological Process	GO:0070351	negative regulation of white fat cell proliferation	IDA	J:208361
Biological Process	GO:0150076	neuroinflammatory response	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:19201
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IDA	J:112035
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IDA	J:98326
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IDA	J:268118
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	ISO	J:155856
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IBA	J:265628
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	IDA	J:274783
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:30239
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:100706
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:62630
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:64603
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:106733
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:1901857	positive regulation of cellular respiration	IDA	J:274783
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:38368
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:214452
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:155856
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IBA	J:265628
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:26926
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175335
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:26926
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:2000424	positive regulation of eosinophil chemotaxis	ISO	J:155856
Biological Process	GO:2000424	positive regulation of eosinophil chemotaxis	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:274783
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IGI	J:100883
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:100883
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:155856
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IBA	J:265628
Biological Process	GO:0032736	positive regulation of interleukin-13 production	ISO	J:164563
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IBA	J:265628
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	IBA	J:265628
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	IDA	J:88910
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IBA	J:265628
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IDA	J:84929
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IDA	J:88910
Biological Process	GO:0016239	positive regulation of macroautophagy	IDA	J:227653
Biological Process	GO:0016239	positive regulation of macroautophagy	IBA	J:265628
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IBA	J:265628
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IMP	J:100883
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IGI	J:100883
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IBA	J:265628
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:88533
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:76115
Biological Process	GO:0071677	positive regulation of mononuclear cell migration	ISO	J:155856
Biological Process	GO:0071677	positive regulation of mononuclear cell migration	IBA	J:265628
Biological Process	GO:1901741	positive regulation of myoblast fusion	IBA	J:265628
Biological Process	GO:1901741	positive regulation of myoblast fusion	IMP	J:107688
Biological Process	GO:1901741	positive regulation of myoblast fusion	IDA	J:107688
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:19201
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:78230
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	IDA	J:268118
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	IBA	J:265628
Biological Process	GO:0045582	positive regulation of T cell differentiation	ISO	J:164563
Biological Process	GO:0045582	positive regulation of T cell differentiation	IBA	J:265628
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:1013
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:143168
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:90824
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:39815
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:18351
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:125784
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:143168
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:1013
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:98326
Biological Process	GO:0050776	regulation of immune response	IDA	J:84929
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0010155	regulation of proton transport	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IDA	J:88533
Biological Process	GO:0042110	T cell activation	ISO	J:164563
Biological Process	GO:0042098	T cell proliferation	IDA	J:1013
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	IGI	J:165738
Biological Process	GO:0045064	T-helper 2 cell differentiation	IBA	J:265628
Biological Process	GO:0045064	T-helper 2 cell differentiation	IDA	J:165738
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:18351
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:125784
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:1013
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:18351
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:1013
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA	J:98326