GO Annotations Graph

• Symbol: Il6
• Name: interleukin 6
• ID: MGI:96559

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IDA	J:129666
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:242717
Molecular Function	GO:0005125	cytokine activity	IDA	J:193599
Molecular Function	GO:0005125	cytokine activity	IDA	J:771
Molecular Function	GO:0005125	cytokine activity	IDA	J:85159
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:155856
Molecular Function	GO:0005138	interleukin-6 receptor binding	IDA	J:1806
Molecular Function	GO:0005515	protein binding	IPI	J:47849
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:68367
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:242717
Cellular Component	GO:0005615	extracellular space	IDA	J:762
Cellular Component	GO:0005615	extracellular space	IDA	J:117165
Cellular Component	GO:0005615	extracellular space	IDA	J:126780
Cellular Component	GO:0005615	extracellular space	IDA	J:66835
Cellular Component	GO:0005615	extracellular space	IDA	J:132126
Cellular Component	GO:0005615	extracellular space	IDA	J:76115
Cellular Component	GO:0005615	extracellular space	IDA	J:194920
Cellular Component	GO:0005615	extracellular space	IDA	J:102933
Cellular Component	GO:0005615	extracellular space	IDA	J:88051
Cellular Component	GO:0005615	extracellular space	IDA	J:84679
Cellular Component	GO:0005615	extracellular space	IDA	J:93342
Cellular Component	GO:0005615	extracellular space	IDA	J:138722
Cellular Component	GO:0005615	extracellular space	IDA	J:143981
Cellular Component	GO:0005615	extracellular space	IDA	J:75400
Cellular Component	GO:0005615	extracellular space	IDA	J:208236
Cellular Component	GO:0005615	extracellular space	IDA	J:221015
Cellular Component	GO:0005615	extracellular space	IDA	J:98417
Cellular Component	GO:0005615	extracellular space	IDA	J:193599
Cellular Component	GO:0005615	extracellular space	IDA	J:96035
Cellular Component	GO:0005615	extracellular space	IDA	J:271862
Cellular Component	GO:0005615	extracellular space	IDA	J:91939
Cellular Component	GO:0005615	extracellular space	IDA	J:147177
Cellular Component	GO:0005896	interleukin-6 receptor complex	ISO	J:164563
Cellular Component	GO:0005896	interleukin-6 receptor complex	IDA	J:260609
Biological Process	GO:0006953	acute-phase response	IEA	J:60000
Biological Process	GO:0060445	branching involved in salivary gland morphogenesis	IMP	J:68367
Biological Process	GO:0060445	branching involved in salivary gland morphogenesis	IDA	J:68367
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:155856
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IDA	J:166840
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	IDA	J:155827
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:269278
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:143745
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:205449
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:173334
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA	J:155827
Biological Process	GO:0098586	cellular response to virus	IMP	J:190912
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0042832	defense response to protozoan	IMP	J:117115
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:139138
Biological Process	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IDA	J:68367
Biological Process	GO:0010467	gene expression	IDA	J:297348
Biological Process	GO:0002314	germinal center B cell differentiation	IMP	J:190912
Biological Process	GO:0070091	glucagon secretion	IMP	J:139138
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IDA	J:179825
Biological Process	GO:0042593	glucose homeostasis	IGI	J:207622
Biological Process	GO:0002384	hepatic immune response	ISO	J:164563
Biological Process	GO:0072574	hepatocyte proliferation	IMP	J:37026
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0090594	inflammatory response to wounding	IDA	J:242717
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IMP	J:37026
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:129666
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:260609
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:1806
Biological Process	GO:0097421	liver regeneration	IMP	J:37026
Biological Process	GO:0046716	muscle cell cellular homeostasis	IGI	J:130429
Biological Process	GO:0002262	myeloid cell homeostasis	IMP	J:208698
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045779	negative regulation of bone resorption	IMP	J:235269
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032682	negative regulation of chemokine production	IDA	J:85159
Biological Process	GO:0032682	negative regulation of chemokine production	IMP	J:85159
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0045721	negative regulation of gluconeogenesis	ISO	J:155856
Biological Process	GO:0046888	negative regulation of hormone secretion	IDA	J:23748
Biological Process	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	IMP	J:235269
Biological Process	GO:0045837	negative regulation of membrane potential	ISO	J:155856
Biological Process	GO:0048635	negative regulation of muscle organ development	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:2000635	negative regulation of primary miRNA processing	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0001781	neutrophil apoptotic process	ISO	J:164563
Biological Process	GO:0001781	neutrophil apoptotic process	IDA	J:85159
Biological Process	GO:0001781	neutrophil apoptotic process	IMP	J:85159
Biological Process	GO:0002675	positive regulation of acute inflammatory response	ISO	J:164563
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0050871	positive regulation of B cell activation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	IGI	J:166692
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	IGI	J:166692
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:771
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:68367
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IDA	J:68367
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:21626
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:21626
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:164563
Biological Process	GO:0014015	positive regulation of gliogenesis	IMP	J:224377
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:190912
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IDA	J:273589
Biological Process	GO:0032745	positive regulation of interleukin-21 production	IDA	J:190912
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:73065
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:73065
Biological Process	GO:1901731	positive regulation of platelet aggregation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:1904894	positive regulation of receptor signaling pathway via STAT	ISO	J:164563
Biological Process	GO:1904894	positive regulation of receptor signaling pathway via STAT	IMP	J:37026
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	IMP	J:235269
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IDA	J:81987
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:129666
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:68367
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:130429
Biological Process	GO:0008360	regulation of cell shape	ISO	J:155856
Biological Process	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	ISO	J:155856
Biological Process	GO:0070092	regulation of glucagon secretion	ISO	J:164563
Biological Process	GO:0070092	regulation of glucagon secretion	IDA	J:179825
Biological Process	GO:0050796	regulation of insulin secretion	IDA	J:179825
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0014823	response to activity	IDA	J:179825
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:164563
Biological Process	GO:0009611	response to wounding	IDA	J:148250
Biological Process	GO:0042110	T cell activation	IGI	J:141227
Biological Process	GO:0061470	T follicular helper cell differentiation	IMP	J:190912
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	IMP	J:115922
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	IDA	J:260609
Biological Process	GO:0045064	T-helper 2 cell differentiation	IDA	J:81987
Biological Process	GO:0010573	vascular endothelial growth factor production	ISO	J:164563