GO Annotations Graph

• Symbol: Il6st
• Name: interleukin 6 signal transducer
• ID: MGI:96560

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	ISO	J:164563
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019970	interleukin-11 binding	IDA	J:21233
Molecular Function	GO:0004921	interleukin-11 receptor activity	IDA	J:21233
Molecular Function	GO:0019981	interleukin-6 binding	ISO	J:164563
Molecular Function	GO:0019981	interleukin-6 binding	IBA	J:265628
Molecular Function	GO:0004915	interleukin-6 receptor activity	ISO	J:164563
Molecular Function	GO:0004915	interleukin-6 receptor activity	IBA	J:265628
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	ISO	J:164563
Molecular Function	GO:0004924	oncostatin-M receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:304576
Molecular Function	GO:0005515	protein binding	IPI	J:201263
Molecular Function	GO:0005515	protein binding	IPI	J:105174
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Cellular Component	GO:0044297	cell body	IDA	J:74068
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:74068
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:68367
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005896	interleukin-6 receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	IDA	J:74068
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0005900	oncostatin-M receptor complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:21233
Biological Process	GO:0005977	glycogen metabolic process	IMP	J:54660
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070106	interleukin-27-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:219844
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060576	intestinal epithelial cell development	ISO	J:164563
Biological Process	GO:0060576	intestinal epithelial cell development	IDA	J:219844
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	ISO	J:164563
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0070104	negative regulation of interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0038165	oncostatin-M-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IMP	J:57039
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:89246
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:219844
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0008593	regulation of Notch signaling pathway	IDA	J:82269
Biological Process	GO:0034097	response to cytokine	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IDA	J:79290
Biological Process	GO:0006642	triglyceride mobilization	ISO	J:155856