GO Annotations Graph

• Symbol: Il7
• Name: interleukin 7
• ID: MGI:96561

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IDA	J:85809
Molecular Function	GO:0005125	cytokine activity	IDA	J:81173
Molecular Function	GO:0005126	cytokine receptor binding	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IDA	J:85809
Molecular Function	GO:0005139	interleukin-7 receptor binding	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1295758
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1295764
Cellular Component	GO:0005615	extracellular space	IDA	J:37476
Biological Process	GO:0042100	B cell proliferation	IGI	J:28795
Biological Process	GO:0045453	bone resorption	IDA	J:81173
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:56164
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:42039
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0043086	negative regulation of catalytic activity	IDA	J:37476
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IDA	J:56164
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:37476
Biological Process	GO:0035265	organ growth	IGI	J:42039
Biological Process	GO:0035265	organ growth	IMP	J:42039
Biological Process	GO:0045579	positive regulation of B cell differentiation	IDA	J:111910
Biological Process	GO:0030890	positive regulation of B cell proliferation	IGI	J:28795
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:85809
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:111910
Biological Process	GO:0046622	positive regulation of organ growth	IMP	J:42039
Biological Process	GO:0046622	positive regulation of organ growth	IGI	J:42039
Biological Process	GO:0045582	positive regulation of T cell differentiation	IDA	J:88139
Biological Process	GO:0010468	regulation of gene expression	IDA	J:37476
Biological Process	GO:0010468	regulation of gene expression	IMP	J:42039
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IDA	J:260356
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:42039