GO Annotations Graph

• Symbol: Ins2
• Name: insulin II
• ID: MGI:96573

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	IBA	J:265628
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:326653
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:326653
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:326653
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ISO	J:326653
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ISO	J:326653
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ISO	J:326653
Molecular Function	GO:0008270	zinc ion binding	ISO	J:327401
Molecular Function	GO:0008270	zinc ion binding	IGI	J:162163
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0005737	cytoplasm	IDA	J:105207
Cellular Component	GO:0005829	cytosol	IDA	J:182176
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-9770101
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-216883
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:253547
Cellular Component	GO:0005615	extracellular space	IDA	J:45717
Cellular Component	GO:0005634	nucleus	IDA	J:80826
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:100746
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-216806
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-216852
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-216883
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-9023194
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-9023204
Cellular Component	GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	IDA	J:80826
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0006953	acute-phase response	ISO	J:164563
Biological Process	GO:0046631	alpha-beta T cell activation	ISO	J:164563
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0006983	ER overload response	IMP	J:74700
Biological Process	GO:0055089	fatty acid homeostasis	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IBA	J:265628
Biological Process	GO:0042593	glucose homeostasis	IMP	J:208584
Biological Process	GO:0006006	glucose metabolic process	IMP	J:74700
Biological Process	GO:1904659	glucose transmembrane transport	TAS	J:79240
Biological Process	GO:0030070	insulin processing	ISO	J:327401
Biological Process	GO:0030070	insulin processing	IGI	J:162163
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:326639
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:326653
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:326653
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:83950
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:74700
Biological Process	GO:0016042	lipid catabolic process	IDA	J:83950
Biological Process	GO:0007520	myoblast fusion	IGI	J:95052
Biological Process	GO:0007520	myoblast fusion	IGI	J:95052
Biological Process	GO:0014902	myotube differentiation	IGI	J:95052
Biological Process	GO:0014902	myotube differentiation	IGI	J:95052
Biological Process	GO:0002674	negative regulation of acute inflammatory response	ISO	J:164563
Biological Process	GO:0045922	negative regulation of fatty acid metabolic process	ISO	J:164563
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045818	negative regulation of glycogen catabolic process	ISO	J:164563
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0033861	negative regulation of NAD(P)H oxidase activity	ISO	J:164563
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:164563
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	ISO	J:164563
Biological Process	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:49085
Biological Process	GO:1990535	neuron projection maintenance	ISO	J:164563
Biological Process	GO:0038060	nitric oxide-cGMP-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:1902952	positive regulation of dendritic spine maintenance	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:79150
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0045821	positive regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:204720
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IDA	J:107119
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0050714	positive regulation of protein secretion	IBA	J:265628
Biological Process	GO:0060267	positive regulation of respiratory burst	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	IDA	J:326634
Biological Process	GO:0006521	regulation of cellular amino acid metabolic process	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IDA	J:149618
Biological Process	GO:0042325	regulation of phosphorylation	IDA	J:79150
Biological Process	GO:0043393	regulation of protein binding	IDA	J:46536
Biological Process	GO:0032880	regulation of protein localization	ISO	J:164563
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0050708	regulation of protein secretion	ISO	J:164563
Biological Process	GO:0022898	regulation of transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0042311	vasodilation	ISO	J:164563
Biological Process	GO:0042060	wound healing	ISO	J:164563