GO Annotations Graph

• Symbol: Itga2
• Name: integrin alpha 2
• ID: MGI:96600

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	IDA	J:243536
Molecular Function	GO:0005518	collagen binding	ISO	J:155856
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0098639	collagen binding involved in cell-matrix adhesion	ISO	J:164563
Molecular Function	GO:0038064	collagen receptor activity	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0043236	laminin binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0045178	basal part of cell	IDA	J:74274
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:193934
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:164687
Cellular Component	GO:0009986	cell surface	IDA	J:256075
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:87433
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:151768
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0034666	integrin alpha2-beta1 complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-445068
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0031589	cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0038065	collagen-activated signaling pathway	ISO	J:164563
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0045184	establishment of protein localization	ISO	J:155856
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:155856
Biological Process	GO:0006971	hypotonic response	ISO	J:155856
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0010694	positive regulation of alkaline phosphatase activity	ISO	J:155856
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0031346	positive regulation of cell projection organization	ISO	J:155856
Biological Process	GO:0033343	positive regulation of collagen binding	ISO	J:155856
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0002687	positive regulation of leukocyte migration	ISO	J:155856
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:155856
Biological Process	GO:0050927	positive regulation of positive chemotaxis	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	ISO	J:155856
Biological Process	GO:0043589	skin morphogenesis	ISO	J:155856
Biological Process	GO:0006929	substrate-dependent cell migration	ISO	J:164563