GO Annotations Graph

• Symbol: Itgal
• Name: integrin alpha L
• ID: MGI:96606

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0030369	ICAM-3 receptor activity	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:19636
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:125138
Cellular Component	GO:0001772	immunological synapse	IDA	J:89810
Cellular Component	GO:0034687	integrin alphaL-beta2 complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:90954
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:125144
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:125144
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:155856
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:265617
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	IMP	J:125139
Biological Process	GO:0007159	leukocyte cell-cell adhesion	IDA	J:125144
Biological Process	GO:0007159	leukocyte cell-cell adhesion	IDA	J:89810
Biological Process	GO:0035683	memory T cell extravasation	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IDA	J:125144
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	IMP	J:125147
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:125147
Biological Process	GO:0043113	receptor clustering	ISO	J:164563
Biological Process	GO:0022407	regulation of cell-cell adhesion	IDA	J:125144
Biological Process	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO	J:164563