GO Annotations Graph

• Symbol: Itgam
• Name: integrin alpha M
• ID: MGI:96607

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0038024	cargo receptor activity	IGI	J:183868
Molecular Function	GO:0038024	cargo receptor activity	IMP	J:242546
Molecular Function	GO:0001851	complement component C3b binding	IGI	J:242546
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	IDA	J:19636
Molecular Function	GO:0008201	heparin binding	IDA	J:19636
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0001846	opsonin binding	IDA	J:89997
Molecular Function	GO:0001846	opsonin binding	IMP	J:89997
Molecular Function	GO:0005515	protein binding	IPI	J:254528
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:43157
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31364
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:152384
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:89997
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31133
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:163607
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:97945
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:97996
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:19636
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:35057
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:160232
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:89320
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:86758
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141377
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:202604
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:125138
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0034688	integrin alphaM-beta2 complex	IMP	J:242546
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:81642
Cellular Component	GO:0005634	nucleus	IDA	J:91206
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:52128
Cellular Component	GO:0005886	plasma membrane	IDA	J:38052
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:90954
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:183868
Biological Process	GO:0097242	amyloid-beta clearance	IGI	J:242546
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:140167
Biological Process	GO:0007155	cell adhesion	IMP	J:83226
Biological Process	GO:0007155	cell adhesion	IGI	J:147736
Biological Process	GO:0007155	cell adhesion	IGI	J:147736
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	IMP	J:263413
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106527
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106527
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106527
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0045123	cellular extravasation	IMP	J:83226
Biological Process	GO:0150062	complement-mediated synapse pruning	IMP	J:263413
Biological Process	GO:0030900	forebrain development	IDA	J:140167
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0061756	leukocyte adhesion to vascular endothelial cell	IMP	J:38052
Biological Process	GO:0007159	leukocyte cell-cell adhesion	IMP	J:125139
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IMP	J:198197
Biological Process	GO:0014005	microglia development	IDA	J:167272
Biological Process	GO:0001774	microglial cell activation	IMP	J:140934
Biological Process	GO:0001774	microglial cell activation	IMP	J:140934
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	IDA	J:140934
Biological Process	GO:0001781	neutrophil apoptotic process	IMP	J:38052
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:83226
Biological Process	GO:0006909	phagocytosis	IMP	J:38052
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:183868
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:242546
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:263413
Biological Process	GO:0110090	positive regulation of hippocampal neuron apoptotic process	IDA	J:140167
Biological Process	GO:0060376	positive regulation of mast cell differentiation	IMP	J:52128
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IMP	J:140167
Biological Process	GO:1901216	positive regulation of neuron death	IMP	J:140934
Biological Process	GO:0043315	positive regulation of neutrophil degranulation	ISO	J:164563
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	IMP	J:140934
Biological Process	GO:2000363	positive regulation of prostaglandin-E synthase activity	IMP	J:140934
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IMP	J:140934
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:164563
Biological Process	GO:0032930	positive regulation of superoxide anion generation	IMP	J:140934
Biological Process	GO:0032930	positive regulation of superoxide anion generation	IDA	J:140167
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:183868
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:242546
Biological Process	GO:0150064	vertebrate eye-specific patterning	IMP	J:263413