GO Annotations Graph

• Symbol: Itgav
• Name: integrin alpha V
• ID: MGI:96608

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019960	C-X3-C chemokine binding	ISO	J:164563
Molecular Function	GO:0050840	extracellular matrix binding	ISO	J:164563
Molecular Function	GO:1990430	extracellular matrix protein binding	ISO	J:164563
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0031994	insulin-like growth factor I binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IPI	J:175331
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0038132	neuregulin binding	ISO	J:164563
Molecular Function	GO:0001846	opsonin binding	IDA	J:175331
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IDA	J:175183
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Cellular Component	GO:0035868	alphav-beta3 integrin-HMGB1 complex	ISO	J:164563
Cellular Component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:125138
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:47279
Cellular Component	GO:0031527	filopodium membrane	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:254431
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ISO	J:164563
Cellular Component	GO:0034683	integrin alphav-beta3 complex	TAS	J:175362
Cellular Component	GO:0034684	integrin alphav-beta5 complex	ISO	J:164563
Cellular Component	GO:0034684	integrin alphav-beta5 complex	IDA	J:175331
Cellular Component	GO:0034685	integrin alphav-beta6 complex	ISO	J:164563
Cellular Component	GO:0034685	integrin alphav-beta6 complex	IDA	J:210448
Cellular Component	GO:0034686	integrin alphav-beta8 complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0031258	lamellipodium membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:156924
Cellular Component	GO:0031528	microvillus membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:180687
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-2731130
Cellular Component	GO:0005886	plasma membrane	IDA	J:86627
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0043277	apoptotic cell clearance	IGI	J:175331
Biological Process	GO:0043277	apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0043277	apoptotic cell clearance	IDA	J:175331
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:106377
Biological Process	GO:0001568	blood vessel development	IMP	J:79611
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	IDA	J:210448
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	NAS	J:319996
Biological Process	GO:0007160	cell-matrix adhesion	TAS	J:175362
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0031589	cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0032490	detection of molecule of bacterial origin	TAS	J:175123
Biological Process	GO:0035987	endodermal cell differentiation	ISO	J:164563
Biological Process	GO:0043542	endothelial cell migration	TAS	J:175211
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:175183
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:96457
Biological Process	GO:0009566	fertilization	NAS	J:156924
Biological Process	GO:0048041	focal adhesion assembly	NAS	J:175201
Biological Process	GO:0035262	gonad morphogenesis	NAS	J:108966
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	TAS	J:175331
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	ISO	J:164563
Biological Process	GO:2000536	negative regulation of entry of bacterium into host cell	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010888	negative regulation of lipid storage	ISO	J:164563
Biological Process	GO:0032369	negative regulation of lipid transport	ISO	J:164563
Biological Process	GO:0050748	negative regulation of lipoprotein metabolic process	ISO	J:164563
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ISO	J:164563
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:172937
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	ISO	J:164563
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IMP	J:172937
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	ISO	J:164563
Biological Process	GO:0045124	regulation of bone resorption	TAS	J:175183
Biological Process	GO:0050764	regulation of phagocytosis	NAS	J:175312
Biological Process	GO:0050764	regulation of phagocytosis	ISO	J:164563
Biological Process	GO:1901388	regulation of transforming growth factor beta activation	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	TAS	J:175183
Biological Process	GO:0071731	response to nitric oxide	TAS	J:175313
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0042110	T cell activation	TAS	J:175211
Biological Process	GO:0071604	transforming growth factor beta production	IDA	J:210448
Biological Process	GO:0060707	trophoblast giant cell differentiation	TAS	J:152946
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563