GO Annotations Graph

• Symbol: Itgb1
• Name: integrin beta 1 (fibronectin receptor beta)
• ID: MGI:96610

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:155856
Molecular Function	GO:0019960	C-X3-C chemokine binding	ISO	J:164563
Molecular Function	GO:0019960	C-X3-C chemokine binding	IBA	J:265628
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	ISO	J:155856
Molecular Function	GO:0098639	collagen binding involved in cell-matrix adhesion	ISO	J:164563
Molecular Function	GO:0098639	collagen binding involved in cell-matrix adhesion	IBA	J:265628
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	ISO	J:155856
Molecular Function	GO:0001968	fibronectin binding	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	IPI	J:28224
Molecular Function	GO:0005178	integrin binding	IPI	J:31981
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0043236	laminin binding	ISO	J:155856
Molecular Function	GO:0043236	laminin binding	IBA	J:265628
Molecular Function	GO:0043236	laminin binding	IDA	J:198552
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:173731
Molecular Function	GO:0005515	protein binding	IPI	J:172000
Molecular Function	GO:0005515	protein binding	IPI	J:121431
Molecular Function	GO:0005515	protein binding	IPI	J:59402
Molecular Function	GO:0005515	protein binding	IPI	J:273507
Molecular Function	GO:0005515	protein binding	IPI	J:133659
Molecular Function	GO:0005515	protein binding	IPI	J:215661
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:314094
Molecular Function	GO:0005515	protein binding	IPI	J:221563
Molecular Function	GO:0005515	protein binding	IPI	J:227372
Molecular Function	GO:0005515	protein binding	IPI	J:182501
Molecular Function	GO:0005515	protein binding	IPI	J:84858
Molecular Function	GO:0005515	protein binding	IPI	J:85409
Molecular Function	GO:0005515	protein binding	IPI	J:96950
Molecular Function	GO:0005515	protein binding	IPI	J:142596
Molecular Function	GO:0005515	protein binding	IPI	J:84858
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IDA	J:193934
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:200103
Cellular Component	GO:0009986	cell surface	IDA	J:16243
Cellular Component	GO:0005911	cell-cell junction	ISO	J:155856
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:211258
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IMP	J:211258
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:215661
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IDA	J:182501
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:47279
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:158532
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:163218
Cellular Component	GO:0030175	filopodium	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	ISO	J:73065
Cellular Component	GO:0005925	focal adhesion	ISO	J:254431
Cellular Component	GO:0097386	glial cell projection	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098690	glycinergic synapse	ISO	J:155856
Cellular Component	GO:0030056	hemidesmosome	ISO	J:155856
Cellular Component	GO:0034665	integrin alpha1-beta1 complex	ISO	J:164563
Cellular Component	GO:0034680	integrin alpha10-beta1 complex	ISO	J:164563
Cellular Component	GO:0034681	integrin alpha11-beta1 complex	ISO	J:164563
Cellular Component	GO:0034666	integrin alpha2-beta1 complex	ISO	J:164563
Cellular Component	GO:0034667	integrin alpha3-beta1 complex	ISO	J:155856
Cellular Component	GO:0034667	integrin alpha3-beta1 complex	ISO	J:164563
Cellular Component	GO:0034674	integrin alpha5-beta1 complex	ISO	J:164563
Cellular Component	GO:0034677	integrin alpha7-beta1 complex	IDA	J:142018
Cellular Component	GO:0034677	integrin alpha7-beta1 complex	IPI	J:198552
Cellular Component	GO:0034679	integrin alpha9-beta1 complex	ISO	J:155856
Cellular Component	GO:0008305	integrin complex	ISO	J:155856
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0014704	intercalated disc	IDA	J:73178
Cellular Component	GO:0016020	membrane	IDA	J:227372
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0035748	myelin sheath abaxonal region	IDA	J:159103
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:44406
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:73065
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:215661
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:215661
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-434991
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-445068
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-4085131
Cellular Component	GO:0005886	plasma membrane	IDA	J:85994
Cellular Component	GO:0005886	plasma membrane	IDA	J:82124
Cellular Component	GO:0005886	plasma membrane	IDA	J:82761
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	IDA	J:44406
Cellular Component	GO:0042383	sarcolemma	IDA	J:44406
Cellular Component	GO:0042383	sarcolemma	ISO	J:73065
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:114964
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:114964
Cellular Component	GO:0045202	synapse	IDA	J:84858
Cellular Component	GO:0097060	synaptic membrane	IDA	J:182501
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Biological Process	GO:0048675	axon extension	IMP	J:87191
Biological Process	GO:0048675	axon extension	IGI	J:87191
Biological Process	GO:0071711	basement membrane organization	IMP	J:210448
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:155856
Biological Process	GO:0007161	calcium-independent cell-matrix adhesion	ISO	J:73065
Biological Process	GO:0060912	cardiac cell fate specification	IMP	J:37583
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:37583
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	IMP	J:37583
Biological Process	GO:0023035	CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:155856
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	IMP	J:105463
Biological Process	GO:0008283	cell population proliferation	IMP	J:96910
Biological Process	GO:0030030	cell projection organization	ISO	J:155856
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	IMP	J:170581
Biological Process	GO:0007160	cell-matrix adhesion	IGI	J:118544
Biological Process	GO:0031589	cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	IDA	J:227372
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:182501
Biological Process	GO:0048813	dendrite morphogenesis	IGI	J:182501
Biological Process	GO:0000132	establishment of mitotic spindle orientation	ISO	J:164563
Biological Process	GO:0021943	formation of radial glial scaffolds	IMP	J:170581
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:85594
Biological Process	GO:0008354	germ cell migration	IMP	J:55247
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0001701	in utero embryonic development	IMP	J:28330
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0030032	lamellipodium assembly	ISO	J:155856
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050901	leukocyte tethering or rolling	ISO	J:164563
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:114964
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:114964
Biological Process	GO:0007517	muscle organ development	IEA	J:60000
Biological Process	GO:0048626	myoblast fate specification	IMP	J:37583
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0031345	negative regulation of cell projection organization	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:96910
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	IGI	J:182501
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	IGI	J:182501
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:96910
Biological Process	GO:0030182	neuron differentiation	IMP	J:96910
Biological Process	GO:0031175	neuron projection development	IMP	J:146203
Biological Process	GO:0006909	phagocytosis	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:73065
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ISO	J:155856
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:164563
Biological Process	GO:0051951	positive regulation of glutamate uptake involved in transmission of nerve impulse	IMP	J:219851
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IMP	J:96910
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0032594	protein transport within lipid bilayer	ISO	J:155856
Biological Process	GO:0150103	reactive gliosis	IMP	J:219851
Biological Process	GO:0031623	receptor internalization	IDA	J:227372
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:85994
Biological Process	GO:0010710	regulation of collagen catabolic process	ISO	J:164563
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:1901979	regulation of inward rectifier potassium channel activity	IMP	J:219851
Biological Process	GO:0150054	regulation of postsynaptic neurotransmitter receptor diffusion trapping	ISO	J:155856
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	IMP	J:219851
Biological Process	GO:1905806	regulation of synapse pruning	IDA	J:211258
Biological Process	GO:1905806	regulation of synapse pruning	IMP	J:211258
Biological Process	GO:0045214	sarcomere organization	IMP	J:37583
Biological Process	GO:0001894	tissue homeostasis	ISO	J:155856
Biological Process	GO:0008542	visual learning	IGI	J:182501
Biological Process	GO:0008542	visual learning	IMP	J:182501