GO Annotations Graph

• Symbol: Itgb2
• Name: integrin beta 2
• ID: MGI:96611

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	IMP	J:247468
Molecular Function	GO:0001540	amyloid-beta binding	IBA	J:265628
Molecular Function	GO:0038024	cargo receptor activity	IMP	J:242546
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0001851	complement component C3b binding	IGI	J:242546
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0030369	ICAM-3 receptor activity	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:227372
Molecular Function	GO:0005515	protein binding	IPI	J:146783
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:113020
Cellular Component	GO:0009986	cell surface	ISO	J:200103
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:147119
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0034687	integrin alphaL-beta2 complex	ISO	J:164563
Cellular Component	GO:0034688	integrin alphaM-beta2 complex	IMP	J:242546
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:227372
Cellular Component	GO:0016020	membrane	IDA	J:125134
Cellular Component	GO:0045121	membrane raft	IDA	J:125134
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:90954
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:242546
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IGI	J:147736
Biological Process	GO:0007155	cell adhesion	IGI	J:147736
Biological Process	GO:0007155	cell adhesion	IMP	J:83226
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:265617
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:155856
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106527
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106527
Biological Process	GO:0098609	cell-cell adhesion	IGI	J:106527
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0045123	cellular extravasation	ISO	J:155856
Biological Process	GO:0045123	cellular extravasation	IMP	J:83226
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	IDA	J:227372
Biological Process	GO:0043542	endothelial cell migration	ISO	J:155856
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0007229	integrin-mediated signaling pathway	IDA	J:91862
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:155856
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	ISO	J:155856
Biological Process	GO:0030101	natural killer cell activation	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:83226
Biological Process	GO:1990266	neutrophil migration	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:242546
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	IMP	J:209651
Biological Process	GO:0043315	positive regulation of neutrophil degranulation	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:164563
Biological Process	GO:0043113	receptor clustering	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	IDA	J:227372
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:242546
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563