GO Annotations Graph

• Symbol: Itgb3
• Name: integrin beta 3
• ID: MGI:96612

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019960	C-X3-C chemokine binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:173540
Molecular Function	GO:0050840	extracellular matrix binding	ISO	J:164563
Molecular Function	GO:0070051	fibrinogen binding	ISO	J:155856
Molecular Function	GO:0070051	fibrinogen binding	IBA	J:265628
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0001968	fibronectin binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0031994	insulin-like growth factor I binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	IPI	J:31981
Molecular Function	GO:0038132	neuregulin binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:250837
Molecular Function	GO:0005515	protein binding	IPI	J:133659
Molecular Function	GO:0005515	protein binding	IPI	J:84472
Molecular Function	GO:0005515	protein binding	IPI	J:84472
Molecular Function	GO:0005515	protein binding	IPI	J:205705
Molecular Function	GO:0005515	protein binding	IPI	J:246351
Molecular Function	GO:0005515	protein binding	IPI	J:244748
Molecular Function	GO:0003756	protein disulfide isomerase activity	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IPI	J:175183
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	ISO	J:164563
Cellular Component	GO:0071133	alpha9-beta1 integrin-ADAM8 complex	IDA	J:128102
Cellular Component	GO:0035868	alphav-beta3 integrin-HMGB1 complex	ISO	J:164563
Cellular Component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	ISO	J:164563
Cellular Component	GO:0035866	alphav-beta3 integrin-PKCalpha complex	IDA	J:175183
Cellular Component	GO:0035866	alphav-beta3 integrin-PKCalpha complex	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:103508
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:173540
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:244748
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84599
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:202604
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:47279
Cellular Component	GO:0031527	filopodium membrane	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IDA	J:250837
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:105648
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:105648
Cellular Component	GO:0098690	glycinergic synapse	ISO	J:155856
Cellular Component	GO:0034679	integrin alpha9-beta1 complex	TAS	J:128102
Cellular Component	GO:0034683	integrin alphav-beta3 complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	ISO	J:155856
Cellular Component	GO:0008305	integrin complex	ISO	J:164563
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0031258	lamellipodium membrane	ISO	J:164563
Cellular Component	GO:0042470	melanosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031528	microvillus membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:180687
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:250837
Cellular Component	GO:0097060	synaptic membrane	IEP	J:105648
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Cellular Component	GO:0097060	synaptic membrane	IDA	J:105648
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0043277	apoptotic cell clearance	IGI	J:175331
Biological Process	GO:0043277	apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0072378	blood coagulation, fibrin clot formation	IMP	J:244748
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0048858	cell projection morphogenesis	IC	J:128102
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	IGI	J:118544
Biological Process	GO:0031589	cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0007044	cell-substrate junction assembly	IDA	J:84472
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IMP	J:191757
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	ISO	J:155856
Biological Process	GO:0050919	negative chemotaxis	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0010888	negative regulation of lipid storage	ISO	J:164563
Biological Process	GO:0032369	negative regulation of lipid transport	ISO	J:164563
Biological Process	GO:0050748	negative regulation of lipoprotein metabolic process	ISO	J:164563
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ISO	J:164563
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0030168	platelet activation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	ISO	J:155856
Biological Process	GO:0070527	platelet aggregation	IMP	J:244748
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:191757
Biological Process	GO:1900731	positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	IC	J:128102
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:172937
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	IMP	J:191757
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	IMP	J:191757
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:191757
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:224690
Biological Process	GO:0072126	positive regulation of glomerular mesangial cell proliferation	ISO	J:155856
Biological Process	GO:0002687	positive regulation of leukocyte migration	ISO	J:155856
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IMP	J:172937
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IC	J:128102
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IMP	J:191757
Biological Process	GO:2000406	positive regulation of T cell migration	IDA	J:173540
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IMP	J:224690
Biological Process	GO:1903053	regulation of extracellular matrix organization	IMP	J:191757
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0150054	regulation of postsynaptic neurotransmitter receptor diffusion trapping	ISO	J:155856
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	ISO	J:164563
Biological Process	GO:0032880	regulation of protein localization	IMP	J:250837
Biological Process	GO:0061097	regulation of protein tyrosine kinase activity	IMP	J:191757
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0051611	regulation of serotonin uptake	IMP	J:250837
Biological Process	GO:1901163	regulation of trophoblast cell migration	IMP	J:92219
Biological Process	GO:0014909	smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563