GO Annotations Graph

• Symbol: Itk
• Name: IL2 inducible T cell kinase
• ID: MGI:96621

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:151074
Molecular Function	GO:0005515	protein binding	IPI	J:245321
Molecular Function	GO:0005515	protein binding	IPI	J:248271
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730850
Cellular Component	GO:0005634	nucleus	IDA	J:245321
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007202	activation of phospholipase C activity	IMP	J:54449
Biological Process	GO:0002250	adaptive immune response	IMP	J:54449
Biological Process	GO:0002250	adaptive immune response	IBA	J:265628
Biological Process	GO:0050853	B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0046629	gamma-delta T cell activation	IMP	J:196163
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0032633	interleukin-4 production	IMP	J:131540
Biological Process	GO:0032633	interleukin-4 production	IGI	J:131540
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0001865	NK T cell differentiation	IBA	J:265628
Biological Process	GO:0001865	NK T cell differentiation	IMP	J:131540
Biological Process	GO:0001865	NK T cell differentiation	IMP	J:131540
Biological Process	GO:0001865	NK T cell differentiation	IGI	J:131540
Biological Process	GO:0001865	NK T cell differentiation	IGI	J:131540
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:54449
Biological Process	GO:0006468	protein phosphorylation	IMP	J:245321
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:54449
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0032609	type II interferon production	IMP	J:131540
Biological Process	GO:0032609	type II interferon production	IGI	J:131540