GO Annotations Graph

• Symbol: Itpr1
• Name: inositol 1,4,5-trisphosphate receptor 1
• ID: MGI:96623

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005262	calcium channel activity	IEA	J:72247
Molecular Function	GO:0019855	calcium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0015278	calcium-release channel activity	IDA	J:170219
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	IBA	J:265628
Molecular Function	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IMP	J:265730
Molecular Function	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	EXP	J:265730
Molecular Function	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IDA	J:265730
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	J:170219
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO	J:155856
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IBA	J:265628
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	J:10088
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IGI	J:58572
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IGI	J:58572
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	J:121270
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	TAS	J:73413
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0035091	phosphatidylinositol binding	IDA	J:170219
Molecular Function	GO:0035091	phosphatidylinositol binding	IBA	J:265628
Molecular Function	GO:0035091	phosphatidylinositol binding	IDA	J:34338
Molecular Function	GO:0035091	phosphatidylinositol binding	IDA	J:121270
Molecular Function	GO:0005515	protein binding	IPI	J:203544
Molecular Function	GO:0005515	protein binding	IPI	J:216755
Molecular Function	GO:0005515	protein binding	IPI	J:235425
Molecular Function	GO:0005515	protein binding	IPI	J:220505
Molecular Function	GO:0005515	protein binding	IPI	J:96085
Molecular Function	GO:0005515	protein binding	IPI	J:203544
Molecular Function	GO:0005515	protein binding	IPI	J:234802
Molecular Function	GO:0005515	protein binding	IPI	J:103813
Molecular Function	GO:0005515	protein binding	IPI	J:248286
Molecular Function	GO:0005515	protein binding	IPI	J:298726
Molecular Function	GO:0005515	protein binding	IPI	J:83867
Molecular Function	GO:0005515	protein binding	IPI	J:101279
Molecular Function	GO:0005515	protein binding	IPI	J:101279
Molecular Function	GO:0005515	protein binding	IPI	J:81669
Molecular Function	GO:0005515	protein binding	IPI	J:94387
Molecular Function	GO:0005515	protein binding	IPI	J:101279
Molecular Function	GO:0005515	protein binding	IPI	J:101279
Molecular Function	GO:0005515	protein binding	IPI	J:53344
Molecular Function	GO:0005515	protein binding	IPI	J:122666
Molecular Function	GO:0005515	protein binding	IPI	J:122666
Molecular Function	GO:0005515	protein binding	IPI	J:95748
Molecular Function	GO:0005515	protein binding	IPI	J:126237
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:298726
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0005955	calcineurin complex	IDA	J:126237
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:51940
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:206880
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:216755
Cellular Component	GO:0005783	endoplasmic reticulum	TAS	J:73413
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:95748
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	IDA	J:99797
Cellular Component	GO:0005637	nuclear inner membrane	IDA	J:99797
Cellular Component	GO:0005730	nucleolus	IDA	J:99797
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0031088	platelet dense granule membrane	ISO	J:164563
Cellular Component	GO:0031094	platelet dense tubular network	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:101279
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IPI	J:122666
Cellular Component	GO:0032991	protein-containing complex	IPI	J:122666
Cellular Component	GO:0032991	protein-containing complex	IPI	J:122666
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:99797
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:265730
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:265730
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	EXP	J:265730
Cellular Component	GO:0030667	secretory granule membrane	ISO	J:155856
Cellular Component	GO:0030667	secretory granule membrane	IBA	J:265628
Cellular Component	GO:0030868	smooth endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IPI	J:298726
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:72247
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	IDA	J:99797
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:265730
Biological Process	GO:0000902	cell morphogenesis	IMP	J:298726
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:155856
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IGI	J:95748
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IGI	J:95748
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IGI	J:95748
Biological Process	GO:0042045	epithelial fluid transport	IDA	J:220505
Biological Process	GO:0048016	inositol phosphate-mediated signaling	IDA	J:265730
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:153833
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:284285
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IGI	J:58572
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IMP	J:232958
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:284285
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IGI	J:58572
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IMP	J:232958
Biological Process	GO:0097421	liver regeneration	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0050849	negative regulation of calcium-mediated signaling	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI	J:58572
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:284285
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	J:232958
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:284285
Biological Process	GO:0032024	positive regulation of insulin secretion	IGI	J:58572
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:232958
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0009791	post-embryonic development	IMP	J:122793
Biological Process	GO:0009791	post-embryonic development	IMP	J:122793
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:265730
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:153833
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IDA	J:265730
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	IDA	J:145985
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0050882	voluntary musculoskeletal movement	IMP	J:122793
Biological Process	GO:0050882	voluntary musculoskeletal movement	IMP	J:122793