GO Annotations Graph

• Symbol: Kit
• Name: KIT proto-oncogene receptor tyrosine kinase
• ID: MGI:96677

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	IPI	J:169801
Molecular Function	GO:0005515	protein binding	IPI	J:245391
Molecular Function	GO:0005515	protein binding	IPI	J:89937
Molecular Function	GO:0005515	protein binding	IPI	J:82566
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:10751
Molecular Function	GO:0005515	protein binding	IPI	J:76219
Molecular Function	GO:0005515	protein binding	IPI	J:178186
Molecular Function	GO:0005515	protein binding	IPI	J:64951
Molecular Function	GO:0005515	protein binding	IPI	J:116468
Molecular Function	GO:0005515	protein binding	IPI	J:82566
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	IPI	J:89937
Molecular Function	GO:0005020	stem cell factor receptor activity	IDA	J:62510
Molecular Function	GO:0005020	stem cell factor receptor activity	IDA	J:62510
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:43157
Cellular Component	GO:0009986	cell surface	IDA	J:41397
Cellular Component	GO:0005911	cell-cell junction	IDA	J:195630
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:145577
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:63425
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:144049
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:101855
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:132871
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84889
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84599
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:89706
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:174203
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:155686
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84890
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:99189
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:103896
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1470014
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1524177
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0030183	B cell differentiation	IBA	J:265628
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	TAS	J:78328
Biological Process	GO:0008283	cell population proliferation	IGI	J:59248
Biological Process	GO:0008283	cell population proliferation	IGI	J:59248
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	IDA	J:180565
Biological Process	GO:0006935	chemotaxis	TAS	J:78328
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:62510
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:96391
Biological Process	GO:0048066	developmental pigmentation	IMP	J:133403
Biological Process	GO:0048066	developmental pigmentation	IGI	J:133403
Biological Process	GO:0048066	developmental pigmentation	IMP	J:133403
Biological Process	GO:0048066	developmental pigmentation	IMP	J:133403
Biological Process	GO:0048066	developmental pigmentation	IMP	J:92947
Biological Process	GO:0048565	digestive tract development	IMP	J:89602
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:137091
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:86513
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:163026
Biological Process	GO:0050673	epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:79128
Biological Process	GO:0030218	erythrocyte differentiation	TAS	J:110595
Biological Process	GO:0038162	erythropoietin-mediated signaling pathway	IMP	J:186063
Biological Process	GO:0038093	Fc receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007281	germ cell development	TAS	J:78328
Biological Process	GO:0008354	germ cell migration	ISO	J:155856
Biological Process	GO:0006687	glycosphingolipid metabolic process	IMP	J:137091
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IBA	J:265628
Biological Process	GO:0035701	hematopoietic stem cell migration	IMP	J:178186
Biological Process	GO:0030097	hemopoiesis	IMP	J:76219
Biological Process	GO:0002327	immature B cell differentiation	IMP	J:89602
Biological Process	GO:0006954	inflammatory response	IMP	J:136704
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:62510
Biological Process	GO:0038109	Kit signaling pathway	ISO	J:164563
Biological Process	GO:0038109	Kit signaling pathway	IBA	J:265628
Biological Process	GO:0030032	lamellipodium assembly	IDA	J:186077
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	IGI	J:27238
Biological Process	GO:0002551	mast cell chemotaxis	ISO	J:164563
Biological Process	GO:0043303	mast cell degranulation	ISO	J:164563
Biological Process	GO:0060374	mast cell differentiation	IMP	J:101685
Biological Process	GO:0060374	mast cell differentiation	IMP	J:89602
Biological Process	GO:0060374	mast cell differentiation	IMP	J:133499
Biological Process	GO:0070662	mast cell proliferation	IGI	J:59248
Biological Process	GO:0070662	mast cell proliferation	IGI	J:59248
Biological Process	GO:0035855	megakaryocyte development	IMP	J:89602
Biological Process	GO:0097326	melanocyte adhesion	IDA	J:186166
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:104585
Biological Process	GO:0097324	melanocyte migration	IMP	J:89602
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IGI	J:27238
Biological Process	GO:0051093	negative regulation of developmental process	IMP	J:137091
Biological Process	GO:0043069	negative regulation of programmed cell death	IMP	J:137091
Biological Process	GO:0043069	negative regulation of programmed cell death	IGI	J:86513
Biological Process	GO:2000242	negative regulation of reproductive process	IMP	J:137091
Biological Process	GO:0001541	ovarian follicle development	IMP	J:163026
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043473	pigmentation	IMP	J:89602
Biological Process	GO:0043473	pigmentation	IGI	J:59248
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1904343	positive regulation of colon smooth muscle contraction	ISO	J:155856
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:136704
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:137091
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IGI	J:59248
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IGI	J:59248
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	ISO	J:164563
Biological Process	GO:0070668	positive regulation of mast cell proliferation	IGI	J:59248
Biological Process	GO:0070668	positive regulation of mast cell proliferation	IGI	J:59248
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:155856
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	ISO	J:155856
Biological Process	GO:0120072	positive regulation of pyloric antrum smooth muscle contraction	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:1905065	positive regulation of vascular associated smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	IGI	J:86513
Biological Process	GO:0012501	programmed cell death	IGI	J:86513
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	TAS	J:78328
Biological Process	GO:0006468	protein phosphorylation	IDA	J:76219
Biological Process	GO:1904251	regulation of bile acid metabolic process	ISO	J:155856
Biological Process	GO:0008360	regulation of cell shape	IDA	J:186077
Biological Process	GO:0009314	response to radiation	IMP	J:84568
Biological Process	GO:0048103	somatic stem cell division	ISO	J:155856
Biological Process	GO:0035019	somatic stem cell population maintenance	ISO	J:155856
Biological Process	GO:0007286	spermatid development	IMP	J:137091
Biological Process	GO:0007283	spermatogenesis	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IMP	J:163026
Biological Process	GO:0048863	stem cell differentiation	IMP	J:147651
Biological Process	GO:0030217	T cell differentiation	IMP	J:79128
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0008542	visual learning	ISO	J:155856