GO Annotations Graph

• Symbol: Krt16
• Name: keratin 16
• ID: MGI:96690

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:108710
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IDA	J:80753
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005882	intermediate filament	IDA	J:80753
Cellular Component	GO:0045095	keratin filament	IBA	J:265628
Biological Process	GO:0007568	aging	ISO	J:164563
Biological Process	GO:0030855	epithelial cell differentiation	IBA	J:265628
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:202957
Biological Process	GO:0042633	hair cycle	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:202957
Biological Process	GO:0045087	innate immune response	IMP	J:202957
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IDA	J:80753
Biological Process	GO:0045109	intermediate filament organization	IBA	J:265628
Biological Process	GO:0031424	keratinization	IDA	J:217292
Biological Process	GO:0030216	keratinocyte differentiation	IDA	J:217292
Biological Process	GO:0051546	keratinocyte migration	IDA	J:217292
Biological Process	GO:0002009	morphogenesis of an epithelium	IMP	J:202957
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563