GO Annotations Graph

• Symbol: Lcat
• Name: lecithin cholesterol acyltransferase
• ID: MGI:96755

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO	J:164563
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0034186	apolipoprotein A-I binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008374	O-acyltransferase activity	IEA	J:72247
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	ISO	J:155856
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	ISO	J:164563
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IBA	J:265628
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IDA	J:59687
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	ISO	J:59668
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IDA	J:42632
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	IDA	J:105606
Molecular Function	GO:0004623	phospholipase A2 activity	ISO	J:155856
Molecular Function	GO:0047179	platelet-activating factor acetyltransferase activity	IDA	J:56071
Molecular Function	GO:0047179	platelet-activating factor acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0004771	sterol esterase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:59687
Cellular Component	GO:0005615	extracellular space	ISO	J:59668
Cellular Component	GO:0034364	high-density lipoprotein particle	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:155856
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IDA	J:42632
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:59668
Biological Process	GO:0030301	cholesterol transport	ISO	J:59668
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0042158	lipoprotein biosynthetic process	IDA	J:105606
Biological Process	GO:0042157	lipoprotein metabolic process	ISO	J:155856
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	ISO	J:164563
Biological Process	GO:0046470	phosphatidylcholine metabolic process	ISO	J:164563
Biological Process	GO:0006644	phospholipid metabolic process	ISO	J:164563
Biological Process	GO:0090107	regulation of high-density lipoprotein particle assembly	IDA	J:149650
Biological Process	GO:0046688	response to copper ion	ISO	J:155856
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:155856
Biological Process	GO:0043691	reverse cholesterol transport	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	ISO	J:164563