Lck GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Lck
lymphocyte protein tyrosine kinase
MGI:96756

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003823	antigen binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0042609	CD4 receptor binding	IPI	J:225417
Molecular Function	GO:0042609	CD4 receptor binding	ISO	J:164563
Molecular Function	GO:0042610	CD8 receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:164563
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:1990405	protein antigen binding	IPI	J:170513
Molecular Function	GO:0005515	protein binding	IPI	J:175132
Molecular Function	GO:0005515	protein binding	IPI	J:200350
Molecular Function	GO:0005515	protein binding	IPI	J:159094
Molecular Function	GO:0005515	protein binding	IPI	J:200737
Molecular Function	GO:0005515	protein binding	IPI	J:166023
Molecular Function	GO:0005515	protein binding	IPI	J:116375
Molecular Function	GO:0005515	protein binding	IPI	J:166038
Molecular Function	GO:0005515	protein binding	IPI	J:159071
Molecular Function	GO:0005515	protein binding	IPI	J:58458
Molecular Function	GO:0005515	protein binding	IPI	J:100536
Molecular Function	GO:0005515	protein binding	IPI	J:204615
Molecular Function	GO:0005515	protein binding	IPI	J:115170
Molecular Function	GO:0005515	protein binding	IPI	J:165958
Molecular Function	GO:0005515	protein binding	IPI	J:112392
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:112392
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:213253
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:131771
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:40949
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:172064
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:29834
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:17973
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0042608	T cell receptor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2395436
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0001772	immunological synapse	ISO	J:73065
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0000242	pericentriolar material	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:225417
Cellular Component	GO:0099091	postsynaptic specialization, intracellular component	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:29834
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:40461
Biological Process	GO:0038094	Fc-gamma receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042492	gamma-delta T cell differentiation	IMP	J:22470
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:17973
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:29834
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IMP	J:22470
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:170688
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:68671
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:17973
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:40949
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	IGI	J:170513
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	IDA	J:90029
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IDA	J:113700
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0009612	response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0010038	response to metal ion	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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