Lck GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Lck
lymphocyte protein tyrosine kinase
MGI:96756

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003823	antigen binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0042609	CD4 receptor binding	IPI	J:225417
Molecular Function	GO:0042609	CD4 receptor binding	ISO	J:164563
Molecular Function	GO:0042610	CD8 receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:164563
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:1990405	protein antigen binding	IPI	J:170513
Molecular Function	GO:0005515	protein binding	IPI	J:175132
Molecular Function	GO:0005515	protein binding	IPI	J:200350
Molecular Function	GO:0005515	protein binding	IPI	J:159094
Molecular Function	GO:0005515	protein binding	IPI	J:200737
Molecular Function	GO:0005515	protein binding	IPI	J:166023
Molecular Function	GO:0005515	protein binding	IPI	J:116375
Molecular Function	GO:0005515	protein binding	IPI	J:166038
Molecular Function	GO:0005515	protein binding	IPI	J:159071
Molecular Function	GO:0005515	protein binding	IPI	J:58458
Molecular Function	GO:0005515	protein binding	IPI	J:100536
Molecular Function	GO:0005515	protein binding	IPI	J:204615
Molecular Function	GO:0005515	protein binding	IPI	J:115170
Molecular Function	GO:0005515	protein binding	IPI	J:165958
Molecular Function	GO:0005515	protein binding	IPI	J:112392
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:112392
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:213253
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:131771
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:40949
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:172064
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:29834
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:17973
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0042608	T cell receptor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2395436
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0001772	immunological synapse	ISO	J:73065
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0000242	pericentriolar material	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:225417
Cellular Component	GO:0099091	postsynaptic specialization, intracellular component	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:29834
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:40461
Biological Process	GO:0038094	Fc-gamma receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042492	gamma-delta T cell differentiation	IMP	J:22470
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:17973
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:29834
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IMP	J:22470
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:170688
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050870	positive regulation of T cell activation	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:68671
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:17973
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:40949
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	IGI	J:170513
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	IDA	J:90029
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IDA	J:113700
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0009612	response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0010038	response to metal ion	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	ISO	J:164563
Biological Process	GO:0030217	T cell differentiation	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24