GO Annotations Graph

• Symbol: Lcn2
• Name: lipocalin 2
• ID: MGI:96757

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1903981	enterobactin binding	ISO	J:155856
Molecular Function	GO:1903981	enterobactin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005506	iron ion binding	IDA	J:163136
Molecular Function	GO:0005506	iron ion binding	IDA	J:163023
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0140315	iron ion sequestering activity	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:163136
Molecular Function	GO:0036094	small molecule binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5246466
Cellular Component	GO:0005576	extracellular region	IDA	J:163136
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-5246466
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:271862
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:163136
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IMP	J:106079
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0110091	negative regulation of hippocampal neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0031346	positive regulation of cell projection organization	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:169355
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:155856
Biological Process	GO:1905956	positive regulation of endothelial tube morphogenesis	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1904440	positive regulation of iron ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0009635	response to herbicide	ISO	J:155856
Biological Process	GO:0009615	response to virus	IDA	J:20468
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007614	short-term memory	ISO	J:155856
Biological Process	GO:0015891	siderophore transport	IDA	J:163136
Biological Process	GO:0015891	siderophore transport	IMP	J:163023