Ldlr GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ldlr
low density lipoprotein receptor
MGI:96765

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	IPI	J:241474
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030169	low-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0030169	low-density lipoprotein particle binding	IDA	J:22858
Molecular Function	GO:0030169	low-density lipoprotein particle binding	IDA	J:99809
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	ISO	J:155856
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	ISO	J:164563
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	TAS	Reactome:R-MMU-2425403
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	IMP	J:120283
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	IDA	J:78774
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:84694
Molecular Function	GO:0005515	protein binding	IPI	J:78545
Molecular Function	GO:0030229	very-low-density lipoprotein particle receptor activity	ISO	J:164563
Molecular Function	GO:0030229	very-low-density lipoprotein particle receptor activity	IDA	J:116807
Cellular Component	GO:0045177	apical part of cell	IDA	J:189694
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:189694
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:189694
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:189694
Cellular Component	GO:0009986	cell surface	IDA	J:236595
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:236595
Cellular Component	GO:0005769	early endosome	IDA	J:106641
Cellular Component	GO:0005768	endosome	IDA	J:84694
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005770	late endosome	IDA	J:106641
Cellular Component	GO:0034362	low-density lipoprotein particle	IEA	J:60000
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:106641
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:1990666	PCSK9-LDLR complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:155809
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0055038	recycling endosome membrane	ISO	J:155856
Cellular Component	GO:0036477	somatodendritic compartment	IDA	J:135974
Cellular Component	GO:0097443	sorting endosome	IDA	J:106641
Biological Process	GO:0097242	amyloid-beta clearance	IGI	J:155809
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IDA	J:241474
Biological Process	GO:0048844	artery morphogenesis	IMP	J:212625
Biological Process	GO:0071398	cellular response to fatty acid	IGI	J:223623
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IGI	J:240987
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:198477
Biological Process	GO:0042632	cholesterol homeostasis	IGI	J:66424
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:84694
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:51022
Biological Process	GO:0070508	cholesterol import	IMP	J:133757
Biological Process	GO:0070508	cholesterol import	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:117480
Biological Process	GO:0030301	cholesterol transport	ISO	J:164563
Biological Process	GO:0030301	cholesterol transport	IMP	J:120283
Biological Process	GO:0006897	endocytosis	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:120283
Biological Process	GO:0034384	high-density lipoprotein particle clearance	IGI	J:240987
Biological Process	GO:0030299	intestinal cholesterol absorption	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IGI	J:66424
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0042159	lipoprotein catabolic process	IMP	J:97836
Biological Process	GO:0042159	lipoprotein catabolic process	IDA	J:99809
Biological Process	GO:0042159	lipoprotein catabolic process	IMP	J:51022
Biological Process	GO:0042157	lipoprotein metabolic process	IGI	J:66424
Biological Process	GO:0042157	lipoprotein metabolic process	IGI	J:87974
Biological Process	GO:0007616	long-term memory	IGI	J:211613
Biological Process	GO:0007616	long-term memory	ISO	J:164563
Biological Process	GO:0034383	low-density lipoprotein particle clearance	IMP	J:133757
Biological Process	GO:0034383	low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0034383	low-density lipoprotein particle clearance	IDA	J:236595
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	IGI	J:155809
Biological Process	GO:0061889	negative regulation of astrocyte activation	IGI	J:155809
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:223623
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:1903979	negative regulation of microglial cell activation	IGI	J:155809
Biological Process	GO:0051248	negative regulation of protein metabolic process	IDA	J:241474
Biological Process	GO:0001920	negative regulation of receptor recycling	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IDA	J:241474
Biological Process	GO:0015914	phospholipid transport	IMP	J:133757
Biological Process	GO:0034381	plasma lipoprotein particle clearance	IDA	J:241474
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:223623
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:223623
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:223623
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:223623
Biological Process	GO:1905167	positive regulation of lysosomal protein catabolic process	IDA	J:241474
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	IMP	J:133757
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	IDA	J:155809
Biological Process	GO:0006898	receptor-mediated endocytosis	IDA	J:241474
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	ISO	J:164563
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	IBA	J:265628
Biological Process	GO:0090181	regulation of cholesterol metabolic process	IGI	J:211613
Biological Process	GO:0010899	regulation of phosphatidylcholine catabolic process	IMP	J:133757
Biological Process	GO:0051246	regulation of protein metabolic process	IGI	J:211613
Biological Process	GO:0051246	regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0061771	response to caloric restriction	ISO	J:164563
Biological Process	GO:0061771	response to caloric restriction	IGI	J:211613
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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