GO Annotations Graph

• Symbol: Lif
• Name: leukemia inhibitory factor
• ID: MGI:96787

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:35071
Molecular Function	GO:0005125	cytokine activity	IDA	J:88684
Molecular Function	GO:0005125	cytokine activity	ISO	J:73065
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	ISO	J:73065
Molecular Function	GO:0008083	growth factor activity	IMP	J:35071
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	ISO	J:164563
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	ISO	J:155856
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	IBA	J:265628
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	ISO	J:21233
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0048708	astrocyte differentiation	ISO	J:155856
Biological Process	GO:0001974	blood vessel remodeling	IGI	J:110719
Biological Process	GO:0008283	cell population proliferation	IGI	J:110719
Biological Process	GO:0046697	decidualization	IDA	J:35071
Biological Process	GO:0046697	decidualization	IMP	J:35071
Biological Process	GO:0007566	embryo implantation	IMP	J:35071
Biological Process	GO:0007566	embryo implantation	IDA	J:35071
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:35071
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	ISO	J:164563
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	IBA	J:265628
Biological Process	GO:0048286	lung alveolus development	IGI	J:110719
Biological Process	GO:0048286	lung alveolus development	IGI	J:110719
Biological Process	GO:0048286	lung alveolus development	IGI	J:110719
Biological Process	GO:0030324	lung development	IGI	J:110719
Biological Process	GO:0060463	lung lobe morphogenesis	IGI	J:110719
Biological Process	GO:0060426	lung vasculature development	IGI	J:110719
Biological Process	GO:0060426	lung vasculature development	IGI	J:110719
Biological Process	GO:0060135	maternal process involved in female pregnancy	IMP	J:35071
Biological Process	GO:0140013	meiotic nuclear division	IDA	J:67053
Biological Process	GO:0048644	muscle organ morphogenesis	IMP	J:97380
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:110719
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:110719
Biological Process	GO:0046888	negative regulation of hormone secretion	ISO	J:73065
Biological Process	GO:0045835	negative regulation of meiotic nuclear division	IDA	J:67053
Biological Process	GO:0048666	neuron development	IGI	J:97380
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IDA	J:57039
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0051461	positive regulation of corticotropin secretion	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:35071
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:21626
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:21626
Biological Process	GO:0045651	positive regulation of macrophage differentiation	ISO	J:73065
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:73065
Biological Process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:73065
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:182976
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:182976
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:182976
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:182976
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110719
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0045595	regulation of cell differentiation	IBA	J:265628
Biological Process	GO:0045595	regulation of cell differentiation	IGI	J:103433
Biological Process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	ISO	J:164563
Biological Process	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IDA	J:182976
Biological Process	GO:0060041	retina development in camera-type eye	ISO	J:155856
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:96515
Biological Process	GO:0035019	somatic stem cell population maintenance	IDA	J:96515
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:96515
Biological Process	GO:0060708	spongiotrophoblast differentiation	IGI	J:103433
Biological Process	GO:0048863	stem cell differentiation	IDA	J:190157
Biological Process	GO:0060290	transdifferentiation	ISO	J:155856
Biological Process	GO:0060707	trophoblast giant cell differentiation	IGI	J:103433
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA	J:88684