Lipa GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Lipa
lysosomal acid lipase A
MGI:96789

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	IEA	J:72247
Molecular Function	GO:0016298	lipase activity	ISO	J:164563
Molecular Function	GO:0016298	lipase activity	ISO	J:155856
Molecular Function	GO:0004771	sterol esterase activity	ISO	J:164563
Molecular Function	GO:0004771	sterol esterase activity	ISO	J:155856
Molecular Function	GO:0004771	sterol esterase activity	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IDA	J:170933
Cellular Component	GO:0005764	lysosome	IMP	J:275041
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0002526	acute inflammatory response	IMP	J:275041
Biological Process	GO:1990845	adaptive thermogenesis	IMP	J:261851
Biological Process	GO:0060612	adipose tissue development	IMP	J:261851
Biological Process	GO:0006754	ATP biosynthetic process	IMP	J:208075
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IMP	J:302978
Biological Process	GO:0048539	bone marrow development	IMP	J:160762
Biological Process	GO:0000902	cell morphogenesis	IMP	J:101217
Biological Process	GO:0008283	cell population proliferation	IMP	J:224048
Biological Process	GO:0008283	cell population proliferation	IMP	J:229568
Biological Process	GO:0071838	cell proliferation in bone marrow	IMP	J:160762
Biological Process	GO:0097384	cellular lipid biosynthetic process	IMP	J:275041
Biological Process	GO:0097384	cellular lipid biosynthetic process	IMP	J:275041
Biological Process	GO:0044255	cellular lipid metabolic process	IMP	J:275041
Biological Process	GO:0006695	cholesterol biosynthetic process	IMP	J:227757
Biological Process	GO:0006695	cholesterol biosynthetic process	IMP	J:285128
Biological Process	GO:0033344	cholesterol efflux	IMP	J:285128
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:211848
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:270182
Biological Process	GO:0010878	cholesterol storage	IMP	J:211848
Biological Process	GO:0010878	cholesterol storage	IGI	J:220279
Biological Process	GO:0010878	cholesterol storage	IMP	J:227757
Biological Process	GO:0030301	cholesterol transport	IMP	J:285128
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	IMP	J:208075
Biological Process	GO:0001816	cytokine production	IMP	J:101217
Biological Process	GO:0030421	defecation	IMP	J:227757
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:227757
Biological Process	GO:0006897	endocytosis	IMP	J:302978
Biological Process	GO:0008333	endosome to lysosome transport	IMP	J:302978
Biological Process	GO:0001935	endothelial cell proliferation	IMP	J:302978
Biological Process	GO:0097009	energy homeostasis	IMP	J:270182
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:101217
Biological Process	GO:0070341	fat cell proliferation	IMP	J:302978
Biological Process	GO:0006631	fatty acid metabolic process	ISO	J:155856
Biological Process	GO:0006631	fatty acid metabolic process	IMP	J:261851
Biological Process	GO:0010467	gene expression	IMP	J:146658
Biological Process	GO:0010467	gene expression	IMP	J:208075
Biological Process	GO:0010467	gene expression	IMP	J:224048
Biological Process	GO:0010467	gene expression	IMP	J:227757
Biological Process	GO:0010467	gene expression	IMP	J:261851
Biological Process	GO:0010467	gene expression	IMP	J:277763
Biological Process	GO:0010467	gene expression	IMP	J:285128
Biological Process	GO:0010467	gene expression	IMP	J:302978
Biological Process	GO:0010467	gene expression	IMP	J:304380
Biological Process	GO:0006006	glucose metabolic process	IMP	J:270182
Biological Process	GO:0006096	glycolytic process	IMP	J:229568
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:160762
Biological Process	GO:0030097	hemopoiesis	IMP	J:160762
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:304380
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:101217
Biological Process	GO:0006954	inflammatory response	IMP	J:270182
Biological Process	GO:0006954	inflammatory response	IMP	J:101217
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0055088	lipid homeostasis	IMP	J:270182
Biological Process	GO:0140354	lipid import into cell	IMP	J:261851
Biological Process	GO:0006629	lipid metabolic process	IMP	J:227757
Biological Process	GO:0006629	lipid metabolic process	IMP	J:277763
Biological Process	GO:0006629	lipid metabolic process	IMP	J:285128
Biological Process	GO:0019915	lipid storage	IMP	J:277763
Biological Process	GO:0042159	lipoprotein catabolic process	IMP	J:302978
Biological Process	GO:0001889	liver development	IMP	J:211848
Biological Process	GO:0001889	liver development	IMP	J:227757
Biological Process	GO:0072576	liver morphogenesis	IMP	J:211848
Biological Process	GO:0030324	lung development	IMP	J:101217
Biological Process	GO:0007040	lysosome organization	IMP	J:229568
Biological Process	GO:0007040	lysosome organization	IMP	J:261851
Biological Process	GO:0061519	macrophage homeostasis	IMP	J:101217
Biological Process	GO:0007005	mitochondrion organization	IMP	J:229568
Biological Process	GO:0007005	mitochondrion organization	IMP	J:261851
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:208075
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:224048
Biological Process	GO:0140962	multicellular organismal-level chemical homeostasis	IMP	J:236160
Biological Process	GO:0048871	multicellular organismal-level homeostasis	IMP	J:146658
Biological Process	GO:0033028	myeloid cell apoptotic process	IMP	J:160762
Biological Process	GO:0033028	myeloid cell apoptotic process	IMP	J:208075
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:160762
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:208075
Biological Process	GO:0006638	neutral lipid metabolic process	IMP	J:146658
Biological Process	GO:0071704	organic substance metabolic process	ISO	J:236160
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	IMP	J:146658
Biological Process	GO:0012501	programmed cell death	IMP	J:173597
Biological Process	GO:1903409	reactive oxygen species biosynthetic process	IMP	J:208075
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:229568
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	IMP	J:208075
Biological Process	GO:0002536	respiratory burst involved in inflammatory response	IMP	J:229568
Biological Process	GO:0002536	respiratory burst involved in inflammatory response	IMP	J:302978
Biological Process	GO:0009409	response to cold	IMP	J:261851
Biological Process	GO:0009409	response to cold	IMP	J:302978
Biological Process	GO:0002021	response to dietary excess	IMP	J:270182
Biological Process	GO:0002021	response to dietary excess	IMP	J:277763
Biological Process	GO:0033993	response to lipid	IMP	J:285128
Biological Process	GO:1901355	response to rapamycin	IMP	J:229568
Biological Process	GO:0033189	response to vitamin A	IMP	J:277763
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:211848
Biological Process	GO:0001523	retinoid metabolic process	IMP	J:236160
Biological Process	GO:0007264	small GTPase mediated signal transduction	IMP	J:224048
Biological Process	GO:0048536	spleen development	IMP	J:146658
Biological Process	GO:0016125	sterol metabolic process	ISO	J:155856
Biological Process	GO:0016125	sterol metabolic process	IBA	J:265628
Biological Process	GO:0016125	sterol metabolic process	IMP	J:170933
Biological Process	GO:0016125	sterol metabolic process	IMP	J:173597
Biological Process	GO:0016125	sterol metabolic process	IMP	J:227757
Biological Process	GO:0070231	T cell apoptotic process	IMP	J:146658
Biological Process	GO:0030217	T cell differentiation	IMP	J:146658
Biological Process	GO:0042098	T cell proliferation	IMP	J:146658
Biological Process	GO:0042098	T cell proliferation	IMP	J:208075
Biological Process	GO:0048771	tissue remodeling	IMP	J:101217
Biological Process	GO:0031929	TOR signaling	IMP	J:208075
Biological Process	GO:0031929	TOR signaling	IMP	J:224048
Biological Process	GO:0031929	TOR signaling	IMP	J:229568
Biological Process	GO:0006641	triglyceride metabolic process	IMP	J:270182
Biological Process	GO:0071830	triglyceride-rich lipoprotein particle clearance	IMP	J:302978
Biological Process	GO:0006776	vitamin A metabolic process	IMP	J:236160

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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