GO Annotations Graph

• Symbol: Lmna
• Name: lamin A
• ID: MGI:96794

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:227485
Molecular Function	GO:0005515	protein binding	IPI	J:73171
Molecular Function	GO:0005515	protein binding	IPI	J:104409
Molecular Function	GO:0005515	protein binding	IPI	J:197280
Molecular Function	GO:0005515	protein binding	IPI	J:73171
Molecular Function	GO:0005515	protein binding	IPI	J:104409
Molecular Function	GO:0008157	protein phosphatase 1 binding	ISO	J:155856
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IBA	J:265628
Cellular Component	GO:0005882	intermediate filament	IEA	J:60000
Cellular Component	GO:0005638	lamin filament	IDA	J:19855
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	IDA	J:164709
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	TAS	Reactome:R-MMU-912355
Cellular Component	GO:0005635	nuclear envelope	IBA	J:265628
Cellular Component	GO:0005635	nuclear envelope	IDA	J:160544
Cellular Component	GO:0005635	nuclear envelope	IDA	J:199185
Cellular Component	GO:0005652	nuclear lamina	IBA	J:265628
Cellular Component	GO:0016363	nuclear matrix	ISO	J:155856
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0031965	nuclear membrane	IDA	J:117855
Cellular Component	GO:0031965	nuclear membrane	IDA	J:106641
Cellular Component	GO:0031965	nuclear membrane	IDA	J:303083
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8868356
Cellular Component	GO:0005634	nucleus	IDA	J:227485
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:139951
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:142821
Cellular Component	GO:0005634	nucleus	IDA	J:116472
Cellular Component	GO:0005634	nucleus	IDA	J:251809
Cellular Component	GO:0005634	nucleus	IDA	J:230033
Cellular Component	GO:0005634	nucleus	IDA	J:73171
Cellular Component	GO:0005634	nucleus	IDA	J:155582
Cellular Component	GO:0005634	nucleus	IDA	J:191431
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:1990683	DNA double-strand break attachment to nuclear envelope	ISO	J:164563
Biological Process	GO:0030010	establishment of cell polarity	NAS	J:147687
Biological Process	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	IMP	J:147687
Biological Process	GO:0031507	heterochromatin formation	IBA	J:265628
Biological Process	GO:0007517	muscle organ development	ISO	J:164563
Biological Process	GO:1904178	negative regulation of adipose tissue development	ISO	J:155856
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	IMP	J:227485
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IMP	J:167734
Biological Process	GO:0072201	negative regulation of mesenchymal cell proliferation	IMP	J:191431
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	IMP	J:167734
Biological Process	GO:0006998	nuclear envelope organization	ISO	J:164563
Biological Process	GO:0006998	nuclear envelope organization	IBA	J:265628
Biological Process	GO:0006998	nuclear envelope organization	IGI	J:95274
Biological Process	GO:0007097	nuclear migration	IBA	J:265628
Biological Process	GO:0051664	nuclear pore localization	IBA	J:265628
Biological Process	GO:0006997	nucleus organization	IMP	J:87613
Biological Process	GO:0006997	nucleus organization	IGI	J:106473
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:191431
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0006606	protein import into nucleus	IMP	J:87613
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:0090435	protein localization to nuclear envelope	IBA	J:265628
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:173222
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:105608
Biological Process	GO:0030334	regulation of cell migration	IMP	J:147687
Biological Process	GO:1900180	regulation of protein localization to nucleus	IMP	J:197280
Biological Process	GO:0031647	regulation of protein stability	IMP	J:244335
Biological Process	GO:0032204	regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0055015	ventricular cardiac muscle cell development	IMP	J:87613