GO Annotations Graph

• Symbol: Lpl
• Name: lipoprotein lipase
• ID: MGI:96820

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA	J:72245
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0052689	carboxylic ester hydrolase activity	IEA	J:72247
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016298	lipase activity	IBA	J:265628
Molecular Function	GO:0004465	lipoprotein lipase activity	ISO	J:164563
Molecular Function	GO:0004465	lipoprotein lipase activity	ISO	J:155856
Molecular Function	GO:0004465	lipoprotein lipase activity	IDA	J:9560
Molecular Function	GO:0004465	lipoprotein lipase activity	IDA	J:116807
Molecular Function	GO:0004465	lipoprotein lipase activity	IDA	J:9560
Molecular Function	GO:0071813	lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0052739	phosphatidylserine 1-acylhydrolase activity	IEA	J:72245
Molecular Function	GO:0008970	phospholipase A1 activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:156963
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0017129	triglyceride binding	ISO	J:155856
Molecular Function	GO:0004806	triglyceride lipase activity	ISO	J:164563
Molecular Function	GO:0004806	triglyceride lipase activity	IDA	J:90456
Cellular Component	GO:1902494	catalytic complex	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:162997
Cellular Component	GO:0042627	chylomicron	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:90456
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0034361	very-low-density lipoprotein particle	IEA	J:60000
Biological Process	GO:0071398	cellular response to fatty acid	IDA	J:271696
Biological Process	GO:0031670	cellular response to nutrient	IDA	J:271696
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0034371	chylomicron remodeling	ISO	J:164563
Biological Process	GO:0006633	fatty acid biosynthetic process	ISO	J:164563
Biological Process	GO:0006631	fatty acid metabolic process	ISO	J:164563
Biological Process	GO:0016042	lipid catabolic process	ISO	J:155856
Biological Process	GO:0016042	lipid catabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0055096	low-density lipoprotein particle mediated signaling	ISO	J:164563
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:1904179	positive regulation of adipose tissue development	ISO	J:164563
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IGI	J:271688
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0010886	positive regulation of cholesterol storage	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:271688
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:271688
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:271688
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	IGI	J:64000
Biological Process	GO:0010890	positive regulation of sequestering of triglyceride	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:271688
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0019432	triglyceride biosynthetic process	ISO	J:155856
Biological Process	GO:0019433	triglyceride catabolic process	ISO	J:164563
Biological Process	GO:0019433	triglyceride catabolic process	IDA	J:90456
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:164563
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	ISO	J:164563