GO Annotations Graph

• Symbol: Lrp1
• Name: low density lipoprotein receptor-related protein 1
• ID: MGI:96828

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016964	alpha-2 macroglobulin receptor activity	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	ISO	J:164563
Molecular Function	GO:0034185	apolipoprotein binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	IDA	J:30078
Molecular Function	GO:0038024	cargo receptor activity	IMP	J:241063
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:164563
Molecular Function	GO:0032050	clathrin heavy chain binding	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:180555
Molecular Function	GO:0005515	protein binding	IPI	J:113901
Molecular Function	GO:0005515	protein binding	IPI	J:126870
Molecular Function	GO:0005515	protein binding	IPI	J:273590
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:113901
Molecular Function	GO:0005515	protein binding	IPI	J:170131
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:149003
Molecular Function	GO:0005515	protein binding	IPI	J:126954
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:289252
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	IEA	J:60000
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005769	early endosome	NAS	J:221101
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:147119
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0032593	insulin-responsive compartment	ISO	J:155856
Cellular Component	GO:0062136	low-density lipoprotein receptor complex	NAS	J:137404
Cellular Component	GO:0016020	membrane	IDA	J:90197
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:149003
Cellular Component	GO:0005886	plasma membrane	IDA	J:30078
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:187572
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IMP	J:192453
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IGI	J:204149
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IDA	J:241063
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	ISO	J:164563
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	IDA	J:188234
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	ISO	J:164563
Biological Process	GO:0035909	aorta morphogenesis	IMP	J:153626
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:106377
Biological Process	GO:0002265	astrocyte activation involved in immune response	IGI	J:192453
Biological Process	GO:0003279	cardiac septum development	IMP	J:222159
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0044242	cellular lipid catabolic process	ISO	J:155856
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:192453
Biological Process	GO:0061642	chemoattraction of axon	ISO	J:155856
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:126954
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	IMP	J:289252
Biological Process	GO:0007041	lysosomal transport	IDA	J:227553
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	ISO	J:155856
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:289252
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:289252
Biological Process	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP	J:153626
Biological Process	GO:0060392	negative regulation of SMAD protein signal transduction	IMP	J:289252
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	IMP	J:153626
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IGI	J:289252
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:106811
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:229820
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0048691	positive regulation of axon extension involved in regeneration	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO	J:155856
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IMP	J:152391
Biological Process	GO:1904109	positive regulation of cholesterol import	ISO	J:155856
Biological Process	GO:0032376	positive regulation of cholesterol transport	IDA	J:152391
Biological Process	GO:0048694	positive regulation of collateral sprouting of injured axon	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0032370	positive regulation of lipid transport	IMP	J:152391
Biological Process	GO:1905167	positive regulation of lysosomal protein catabolic process	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0051222	positive regulation of protein transport	ISO	J:155856
Biological Process	GO:1900149	positive regulation of Schwann cell migration	ISO	J:155856
Biological Process	GO:1904300	positive regulation of transcytosis	IMP	J:229820
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:241063
Biological Process	GO:0006898	receptor-mediated endocytosis	IGI	J:204149
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:241063
Biological Process	GO:0006898	receptor-mediated endocytosis	IGI	J:241063
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	IDA	J:174507
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IMP	J:153626
Biological Process	GO:0032374	regulation of cholesterol transport	IMP	J:152391
Biological Process	GO:0032429	regulation of phospholipase A2 activity	IMP	J:152391
Biological Process	GO:1905109	regulation of pulmonary blood vessel remodeling	IMP	J:289252
Biological Process	GO:0150104	transport across blood-brain barrier	IMP	J:229820
Biological Process	GO:0150104	transport across blood-brain barrier	IMP	J:188234